Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Mast Cell Functions Linking Innate Sensing to Adaptive Immunity

Version 1 : Received: 30 October 2020 / Approved: 2 November 2020 / Online: 2 November 2020 (10:27:12 CET)

How to cite: Katsoulis-Dimitriou, K.; Kotrba, J.; Voss, M.; Dudeck, J.; Dudeck, A. Mast Cell Functions Linking Innate Sensing to Adaptive Immunity. Preprints 2020, 2020110016 (doi: 10.20944/preprints202011.0016.v1). Katsoulis-Dimitriou, K.; Kotrba, J.; Voss, M.; Dudeck, J.; Dudeck, A. Mast Cell Functions Linking Innate Sensing to Adaptive Immunity. Preprints 2020, 2020110016 (doi: 10.20944/preprints202011.0016.v1).

Abstract

Although Mast cells are known as key drivers of type I allergic reactions, there is increasing evidence for their critical role in host defense. MCs do not only play an important role in initiating innate immune responses, but also influence the onset, kinetic and amplitude of the adaptive arm of immunity, or fine-tune the mode of the adaptive reaction. Intriguingly, MCs have been shown to affect T cell activation by direct interaction or indirectly by modifying properties of antigen-presenting cells, and can even modulate lymph node-borne adaptive responses remotely from the periphery. In this review, we provide a summary of recent findings that explain how MCs act as a link between the innate and the adaptive immunity, all the way from sensing inflammatory insult to orchestrating the final outcome of the immune response.

Subject Areas

mast cells; adaptive immunity; dendritic cells; T cells

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