Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Unusual Faces of Bladder Cancer

Version 1 : Received: 27 October 2020 / Approved: 29 October 2020 / Online: 29 October 2020 (09:25:10 CET)

A peer-reviewed article of this Preprint also exists.

Manini, C.; López, J.I. Unusual Faces of Bladder Cancer. Cancers 2020, 12, 3706. Manini, C.; López, J.I. Unusual Faces of Bladder Cancer. Cancers 2020, 12, 3706.

Journal reference: Cancers 2020, 12, 3706
DOI: 10.3390/cancers12123706


The overwhelming majority of bladder cancers are transitional cell carcinomas. Albeit mostly monotonous, carcinomas in the bladder may occasionally display a broad spectrum of histological features that should be recognized by pathologists because some of them represent a diagnostic problem and/or lead prognostic implications. Sometimes these features are focal in the context of conventional transitional cell carcinomas, but some others are generalized across the tumor making its recognition a challenge. For practical purposes, the review distributes the morphologic spectrum of changes in architectural and cytological. So, nested and large nested, micropapillary, myxoid stroma, small tubules and adenoma nephrogenic-like, microcystic, verrucous, and diffuse lymphoepithelioma-like, on one hand, and plasmacytoid, signet ring, basaloid-squamous, yolk-sac, trophoblastic, rhabdoid, lipid/lipoblastic, giant, clear, eosinophilic (oncocytoid), and sarcomatoid, on the other, are revisited. Key histological and immunohistochemical features useful in the differential diagnosis are mentioned. In selected cases, molecular data associated with the diagnosis, prognosis, and/or treatment are also included.


Bladder cancer; diagnosis; differential diagnosis; prognosis; histopathology; immunohistochemistry



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