Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Beneficial Roles of Cellulose Patch-Mediated Cell Therapy In Myocardial Infarction: A Preclinical Study

Version 1 : Received: 26 October 2020 / Approved: 28 October 2020 / Online: 28 October 2020 (08:59:09 CET)

How to cite: Simeoni, R.; Francisco, J.C.; Miyague, N.; irioda, A.C.; Souza, C.M.; Souza, D.; Stricker, P.; Rosa, N.; Souza, C.; Mogharbel, B.F.; Guarita-Souza, L.C.; Sierakowski, M.R.; Abdelwahid, E.; Carvalho, K.A.T.D. Beneficial Roles of Cellulose Patch-Mediated Cell Therapy In Myocardial Infarction: A Preclinical Study. Preprints 2020, 2020100573 (doi: 10.20944/preprints202010.0573.v1). Simeoni, R.; Francisco, J.C.; Miyague, N.; irioda, A.C.; Souza, C.M.; Souza, D.; Stricker, P.; Rosa, N.; Souza, C.; Mogharbel, B.F.; Guarita-Souza, L.C.; Sierakowski, M.R.; Abdelwahid, E.; Carvalho, K.A.T.D. Beneficial Roles of Cellulose Patch-Mediated Cell Therapy In Myocardial Infarction: A Preclinical Study. Preprints 2020, 2020100573 (doi: 10.20944/preprints202010.0573.v1).

Abstract

Biologic scaffolds have become an attractive approach for repairing the infarcted myocardium and have been shown to facilitate constructive remodeling in injured tissues. This study aimed to investigate the possible utilization of bacterial cellulose membrane patch containing cocultured cells to limit the myocardium's post-infarction pathology. Myocardial infarction was induced by ligating the left anterior descending coronary artery in 45 Wistar rats, and patches with or without cells were attached to the hearts. After one week, the animals underwent echocardiography for assessing ejection fraction and left ventricular end-diastolic and end-systolic volumes. Following the patch formation, cocultured cells retained viability of >90% over 14 days in culture. The patch was applied to the myocardial surface of the infarcted area after staying 14 days in culture. Interestingly, the bacterial cellulose membrane without cellular treatment showed higher preservation of cardiac dimensions; however, we did not observe improvement in the left ventricular ejection fraction of this group compared to coculture treated membranes. Our results demonstrated an important role for bacterial cellulose in supporting cells known to produce cardioprotective soluble factors and may thus provide effective future therapeutic outcomes for patients suffering from ischemic heart disease.

Subject Areas

implant; bacterial cellulose; patch; myocardial infarction; cell; delivery

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