Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Beneficial Roles of Cellulose Patch-Mediated Cell Therapy In Myocardial Infarction: A Preclinical Study

Rossana Simeoni
,
Julio Cesar Francisco
ORCID logo ,
Nelson Miyague
,
Ana Carolina irioda
,
Carolina Maria Souza
,
Daiany Souza
ORCID logo ,
Priscila Stricker
ORCID logo ,
Nádia Rosa
,
Clayton Souza
ORCID logo ,
Bassam Felipe Mogharbel
ORCID logo ,
Luiz Cesar Guarita-Souza
ORCID logo ,
Maria Rita Sierakowski
,
Eltyeb Abdelwahid
,
Katherine Athayde Teixeira de Carvalho
* ORCID logo
Version 1 : Received: 26 October 2020 / Approved: 28 October 2020 / Online: 28 October 2020 (08:59:09 CET)

A peer-reviewed article of this Preprint also exists.

Simeoni, R.B.; Mogharbel, B.F.; Francisco, J.C.; Miyague, N.I.; Irioda, A.C.; Souza, C.M.C.O.; Souza, D.; Stricker, P.E.F.; da Rosa, N.N.; Souza, C.F.; et al. Beneficial Roles of Cellulose Patch-Mediated Cell Therapy in Myocardial Infarction: A Preclinical Study. Cells 2021, 10, 424, doi:10.3390/cells10020424. Simeoni, R.B.; Mogharbel, B.F.; Francisco, J.C.; Miyague, N.I.; Irioda, A.C.; Souza, C.M.C.O.; Souza, D.; Stricker, P.E.F.; da Rosa, N.N.; Souza, C.F.; et al. Beneficial Roles of Cellulose Patch-Mediated Cell Therapy in Myocardial Infarction: A Preclinical Study. Cells 2021, 10, 424, doi:10.3390/cells10020424.

Abstract

Biologic scaffolds have become an attractive approach for repairing the infarcted myocardium and have been shown to facilitate constructive remodeling in injured tissues. This study aimed to investigate the possible utilization of bacterial cellulose membrane patch containing cocultured cells to limit the myocardium's post-infarction pathology. Myocardial infarction was induced by ligating the left anterior descending coronary artery in 45 Wistar rats, and patches with or without cells were attached to the hearts. After one week, the animals underwent echocardiography for assessing ejection fraction and left ventricular end-diastolic and end-systolic volumes. Following the patch formation, cocultured cells retained viability of >90% over 14 days in culture. The patch was applied to the myocardial surface of the infarcted area after staying 14 days in culture. Interestingly, the bacterial cellulose membrane without cellular treatment showed higher preservation of cardiac dimensions; however, we did not observe improvement in the left ventricular ejection fraction of this group compared to coculture treated membranes. Our results demonstrated an important role for bacterial cellulose in supporting cells known to produce cardioprotective soluble factors and may thus provide effective future therapeutic outcomes for patients suffering from ischemic heart disease.

Keywords

implant; bacterial cellulose; patch; myocardial infarction; cell; delivery

Subject

Medicine and Pharmacology, Immunology and Allergy

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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