Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Non-Coding RNAs: Uncharted Mediators of Thyroid Cancer Pathogenesis

Version 1 : Received: 7 October 2020 / Approved: 7 October 2020 / Online: 7 October 2020 (14:28:40 CEST)

A peer-reviewed article of this Preprint also exists.

Tabatabaeian, H.; Peiling Yang, S.; Tay, Y. Non-Coding RNAs: Uncharted Mediators of Thyroid Cancer Pathogenesis. Cancers 2020, 12, 3264. Tabatabaeian, H.; Peiling Yang, S.; Tay, Y. Non-Coding RNAs: Uncharted Mediators of Thyroid Cancer Pathogenesis. Cancers 2020, 12, 3264.

Journal reference: Cancers 2020, 12, 3264
DOI: 10.3390/cancers12113264

Abstract

Thyroid cancer is the most prevalent malignancy of the endocrine system and the ninth most common cancer globally. Despite the advances in the management of thyroid cancer, there are critical issues with the diagnosis and treatment of thyroid cancer that result in the poor overall survival of undifferentiated and metastatic thyroid cancer patients. Recent studies have revealed the role of different non-coding RNAs (ncRNAs), such as microRNAs (miRNAs), long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) that are dysregulated during thyroid cancer development or the acquisition of resistance to therapeutics, and may play key roles in treatment failure and poor prognosis of the thyroid cancer patients. Here, we systematically review the emerging roles and molecular mechanisms of ncRNAs that regulate thyroid tumorigenesis and drug response. We then propose the potential clinical implications of ncRNAs as novel diagnostic and prognostic biomarkers for thyroid cancer.

Subject Areas

Thyroid carcinoma; non-coding RNA; radioactive iodine; drug resistance; prognosis

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