Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Hypoxia Pathway Proteins are Master Regulators of Erythropoiesis

Version 1 : Received: 5 October 2020 / Approved: 6 October 2020 / Online: 6 October 2020 (15:41:14 CEST)

How to cite: Watts, D.; Gaete, D.; Rodriguez, D.; Hoogewijs, D.; Rauner, M.; Sormendi, S.; Wielockx, B. Hypoxia Pathway Proteins are Master Regulators of Erythropoiesis. Preprints 2020, 2020100136 (doi: 10.20944/preprints202010.0136.v1). Watts, D.; Gaete, D.; Rodriguez, D.; Hoogewijs, D.; Rauner, M.; Sormendi, S.; Wielockx, B. Hypoxia Pathway Proteins are Master Regulators of Erythropoiesis. Preprints 2020, 2020100136 (doi: 10.20944/preprints202010.0136.v1).

Abstract

Erythropoiesis is a complex process driving the production of red blood cells. During homeostasis, adult erythropoiesis takes place in the bone marrow and is tightly controlled by erythropoietin (EPO), a central hormone mainly produced in renal EPO-producing cells. The expression of EPO is strictly regulated by local changes in oxygen partial pressure (pO2) as under deprived oxygen (hypoxia) the transcription factor Hypoxia Inducible Factor-2 induces EPO. However, erythropoiesis regulation extends beyond the well-established HIF-EPO axis, and involves processes modulated by other hypoxia pathway proteins (HPPs), including proteins involved in iron metabolism. The importance of a number of these factors is evident as their altered expression has been associated with various anemia-related disorders, including chronic kidney disease. Eventually, our emerging understanding of HPPs and their regulatory feedback will be instrumental in developing specific therapies for anemic patients and beyond.

Keywords

hypoxia; erythropoiesis; EPO; HIF; CKD

Subject

MEDICINE & PHARMACOLOGY, Allergology

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