Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Zika Virus Infection in a Cohort of Pregnant Women with Exanthematic Disease in Manaus, Brazilian Amazon

Version 1 : Received: 1 October 2020 / Approved: 2 October 2020 / Online: 2 October 2020 (08:47:53 CEST)

How to cite: Redivo, E.D.F.; Bôtto Menezes, C.H.; da Costa Castilho, M.; Facchinetti Brock, M.; da Silva Magno, E.; Gomes Saraiva, M.D.G.; Alvarez Fernandes, S.S.; Costa Antony de Andrade, A.B.; Costa Alecrim, M.D.G.; Martinez-Espinosa, F.E. Zika Virus Infection in a Cohort of Pregnant Women with Exanthematic Disease in Manaus, Brazilian Amazon. Preprints 2020, 2020100030 (doi: 10.20944/preprints202010.0030.v1). Redivo, E.D.F.; Bôtto Menezes, C.H.; da Costa Castilho, M.; Facchinetti Brock, M.; da Silva Magno, E.; Gomes Saraiva, M.D.G.; Alvarez Fernandes, S.S.; Costa Antony de Andrade, A.B.; Costa Alecrim, M.D.G.; Martinez-Espinosa, F.E. Zika Virus Infection in a Cohort of Pregnant Women with Exanthematic Disease in Manaus, Brazilian Amazon. Preprints 2020, 2020100030 (doi: 10.20944/preprints202010.0030.v1).

Abstract

The epidemic transmission of Zika virus (ZIKV) in Brazil has been identified as a cause of microcephaly and other neurological malformations in babies of ZIKV-infected women. This study provides a descriptive analysis, since the onset of symptoms to the delivery, of a cohort who were registered as having ZIKV infection in pregnancy, from November 2015 to December 2016. Suspected cases were registered at a referral center for infectious and tropical diseases in Manaus, in the Brazilian Amazonian region. A total of 834 women with suspected ZIKV in pregnancy were included, of whom 91.4% had confirmed pregnancy. Reverse-transcriptase polymerase chain reaction (RT-PCR) confirmed ZIKV infection in 42.2% of the cohort. In 35.2% of the cohort, ZIKV was the sole infection identified. Severe adverse pregnancy outcomes (abortion, stillbirth, or microcephaly) were observed in both RT-PCR ZIKV-positive (4.96%) and ZIKV-negative (2.15%) cases. Women with suspected ZIKV infection were much more likely to have adverse pregnancy outcomes if they were symptomatic during the first trimester of pregnancy (odds ratio 10.5; 95% confidence interval 4.0–27.0; p<0.001). Among pregnant women with suspected ZIKV infection, the occurrence of symptoms in the first trimester is associated with an especially high risk of severe adverse pregnancy outcomes.

Subject Areas

Amazonian region; ZIKV in pregnancy; Exanthematic disease in pregnancy; Torch syndrome; Abortion; Stillbirth; Mycrocephaly; Preterm delivery; Low birth weight

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