Preprint Communication Version 1 Preserved in Portico This version is not peer-reviewed

The Association between Influenza Vaccination and the Risk of SARS-CoV-2 Infection, Severe Illness, and Death: A Systematic Review of the Literature

Version 1 : Received: 28 September 2020 / Approved: 29 September 2020 / Online: 29 September 2020 (09:14:03 CEST)

How to cite: Del Riccio, M.; Lorini, C.; Bonaccorsi, G.; Paget, J.; Caini, S. The Association between Influenza Vaccination and the Risk of SARS-CoV-2 Infection, Severe Illness, and Death: A Systematic Review of the Literature. Preprints 2020, 2020090702 (doi: 10.20944/preprints202009.0702.v1). Del Riccio, M.; Lorini, C.; Bonaccorsi, G.; Paget, J.; Caini, S. The Association between Influenza Vaccination and the Risk of SARS-CoV-2 Infection, Severe Illness, and Death: A Systematic Review of the Literature. Preprints 2020, 2020090702 (doi: 10.20944/preprints202009.0702.v1).

Abstract

We reviewed the association between seasonal influenza vaccination and the risk of SARS-CoV-2 infection or complicated illness or poor outcome (e.g. severe disease, need for hospitalization or ventilatory support, or death) among COVID-19 patients. None of the studies that were reviewed (n=12) found a significant increase in the risk of infection or in the illness severity or lethality, while some reported significantly inverse associations. Our findings support measures aimed at raising influenza vaccination coverage in the coming months.

Subject Areas

SARS-CoV-2; influenza vaccine; systematic review; infection; severity; risk

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