Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Towards An Integral Therapeutic Protocol for Breast Cancer based upon the New H+-Centered Anticancer Paradigm of the Late Post-Warburg Era

Version 1 : Received: 22 September 2020 / Approved: 23 September 2020 / Online: 23 September 2020 (04:04:24 CEST)

A peer-reviewed article of this Preprint also exists.

Harguindey, S.; Alfarouk, K.; Polo Orozco, J.; Fais, S.; Devesa, J. Towards an Integral Therapeutic Protocol for Breast Cancer Based upon the New H+-Centered Anticancer Paradigm of the Late Post-Warburg Era. Int. J. Mol. Sci. 2020, 21, 7475. Harguindey, S.; Alfarouk, K.; Polo Orozco, J.; Fais, S.; Devesa, J. Towards an Integral Therapeutic Protocol for Breast Cancer Based upon the New H+-Centered Anticancer Paradigm of the Late Post-Warburg Era. Int. J. Mol. Sci. 2020, 21, 7475.

Journal reference: Int. J. Mol. Sci. 2020, 21, 7475
DOI: 10.3390/ijms21207475

Abstract

A brand-new approach to the understanding of breast cancer (BC) is urgently needed. In this contribution, the etiology, pathogenesis, and treatment of this disease is approached from the new pH-centric anticancer paradigm. Only this Unitarian perspective based upon that the hydrogen ion (H+) dynamics of cancer, allows understanding and integrating the many dualisms, confusions, and paradoxes of the disease. The new H+-related wide range model can embrace under a unique frame of mind the many aspects of the disease and at the same time therapeutically interfere with most, if not with all, the hallmarks of cancer known to date. The pH-related armamentarium available for the treatment of BC here reviewed may be beneficial for all types and stages of the disease. In this vein, we have attempted a mega synthesis of traditional and new knowledge in the different areas of breast cancer research and treatment based upon the wide range approach afforded by the hydrogen ion dynamics of cancer. The concerted utilization of a pH-related drugs nowadays available for the treatment of breast cancer is advanced.

Subject Areas

breast cancer etiopathogenesis; breast cancer treatment; hydrogen ion dynamics of cancer; pH-related paradigm; H+-related therapeutics of breast cancer

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