Working Paper Case Report Version 4 This version is not peer-reviewed

SARS-CoV-2 Infection in the Central Nervous System of a 1-Year-Old Infant

Version 1 : Received: 13 September 2020 / Approved: 13 September 2020 / Online: 13 September 2020 (16:16:59 CEST)
Version 2 : Received: 18 September 2020 / Approved: 19 September 2020 / Online: 19 September 2020 (04:49:18 CEST)
Version 3 : Received: 21 October 2020 / Approved: 22 October 2020 / Online: 22 October 2020 (10:43:56 CEST)
Version 4 : Received: 1 December 2020 / Approved: 2 December 2020 / Online: 2 December 2020 (11:45:50 CET)
Version 5 : Received: 11 March 2021 / Approved: 15 March 2021 / Online: 15 March 2021 (13:03:33 CET)

A peer-reviewed article of this Preprint also exists.

Gomes, I.; Karmirian, K.; Oliveira, J. T.; Pedrosa, C. da S. G.; Mendes, M. A.; Rosman, F. C.; Chimelli, L.; Rehen, S. SARS-CoV-2 Infection of the Central Nervous System in a 14-Month-Old Child: A Case Report of a Complete Autopsy. The Lancet Regional Health - Americas, 2021, 2, 100046. https://doi.org/10.1016/j.lana.2021.100046. Gomes, I.; Karmirian, K.; Oliveira, J. T.; Pedrosa, C. da S. G.; Mendes, M. A.; Rosman, F. C.; Chimelli, L.; Rehen, S. SARS-CoV-2 Infection of the Central Nervous System in a 14-Month-Old Child: A Case Report of a Complete Autopsy. The Lancet Regional Health - Americas, 2021, 2, 100046. https://doi.org/10.1016/j.lana.2021.100046.

Abstract

Coronavirus disease 2019 (COVID-19) was initially characterized as a respiratory illness. Neurological manifestations were reported mostly in severely affected patients. Routes for brain infection and the presence of virus particles in situ have not been well described, raising controversy about how the virus causes neurological symptoms. Here, we report the autopsy findings of a 1-year old infant with COVID-19. In addition to pneumonitis and multiple organ damage related to thrombosis, SARS-CoV-2 infected the choroid plexus, ventricles, and cerebral cortex. This is the first evidence of SARS-CoV-2 detection in an infant post-mortem brain.

Keywords

SARS-CoV-2 neuroinvasion; COVID-19; infant; Choroid plexus

Subject

Medicine and Pharmacology, Pathology and Pathobiology

Comments (1)

Comment 1
Received: 2 December 2020
Commenter: Stevens Rehen
Commenter's Conflict of Interests: Author
Comment: New data and corrections.
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