Working Paper Review Version 1 This version is not peer-reviewed

Antioxidant and Biological Properties of the Mesenchymal Cells Used in the Therapeutic Sense during Retinitis Pigmentosa

Version 1 : Received: 7 September 2020 / Approved: 11 September 2020 / Online: 11 September 2020 (08:18:37 CEST)

A peer-reviewed article of this Preprint also exists.

Limoli, P.G.; Vingolo, E.M.; Limoli, C.; Nebbioso, M. Antioxidant and Biological Properties of Mesenchymal Cells Used for Therapy in Retinitis Pigmentosa. Antioxidants 2020, 9, 983. Limoli, P.G.; Vingolo, E.M.; Limoli, C.; Nebbioso, M. Antioxidant and Biological Properties of Mesenchymal Cells Used for Therapy in Retinitis Pigmentosa. Antioxidants 2020, 9, 983.

Journal reference: Antioxidants 2020, 9, 983
DOI: 10.3390/antiox9100983

Abstract

Both tissue repair and regeneration are a priority in regenerative medicine. Retinitis pigmentosa (RP), a complex retinal disease characterized by the progressive loss of impaired photoreceptors, is currently lacking effective therapies: this represents one of the greatest challenge in the ophthalmological research field. Although this inherited retinal dystrophie is still incurable genetic disease, the oxidative damage is an important pathogenetic element that may represent a viable target of therapy. In this review, we summarize the current neuroscientific evidences about the cell therapies effectiveness, especially based on mesenchymal cells, in RP and focus on their therapeutic actions: limitation of both oxidative stress and apoptotic processes triggered by the disease, promoting cell survival. Cell therapy could therefore represent a feasible therapeutic option in RP.

Keywords

Retinitis Pigmentosa; Cell Surgery; Growth Factors; Mesenchimal Cells; oxidative stress

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