Working Paper Review Version 1 This version is not peer-reviewed

Antioxidant and Biological Properties of the Mesenchymal Cells Used in the Therapeutic Sense during Retinitis Pigmentosa

Version 1 : Received: 7 September 2020 / Approved: 11 September 2020 / Online: 11 September 2020 (08:18:37 CEST)

How to cite: Limoli, P.G.; Vingolo, E.M.; Limoli, C.; Nebbioso, M. Antioxidant and Biological Properties of the Mesenchymal Cells Used in the Therapeutic Sense during Retinitis Pigmentosa. Preprints 2020, 2020090248 Limoli, P.G.; Vingolo, E.M.; Limoli, C.; Nebbioso, M. Antioxidant and Biological Properties of the Mesenchymal Cells Used in the Therapeutic Sense during Retinitis Pigmentosa. Preprints 2020, 2020090248

Abstract

Both tissue repair and regeneration are a priority in regenerative medicine. Retinitis pigmentosa (RP), a complex retinal disease characterized by the progressive loss of impaired photoreceptors, is currently lacking effective therapies: this represents one of the greatest challenge in the ophthalmological research field. Although this inherited retinal dystrophie is still incurable genetic disease, the oxidative damage is an important pathogenetic element that may represent a viable target of therapy. In this review, we summarize the current neuroscientific evidences about the cell therapies effectiveness, especially based on mesenchymal cells, in RP and focus on their therapeutic actions: limitation of both oxidative stress and apoptotic processes triggered by the disease, promoting cell survival. Cell therapy could therefore represent a feasible therapeutic option in RP.

Subject Areas

Retinitis Pigmentosa; Cell Surgery; Growth Factors; Mesenchimal Cells; oxidative stress

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our diversity statement.

Leave a public comment
Send a private comment to the author(s)
Views 0
Downloads 0
Comments 0
Metrics 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.