Molecular Pharming to Support Human Life on the Moon, Mars, and Beyond

Matthew J. McNulty; Yongao Xiong; Kevin Yates; Kalimuthu Karuppanan; Jacob M. Hilzinger; Aaron J. Berliner; Jesse Delzio; Adam P. Arkin; Nancy E. Lane; Somen Nandi; Karen A. McDonald

doi:10.20944/preprints202009.0086.v1

Share this article with

Create alert

Email:

Load new image

preprints.org > life sciences > biotechnology > doi: 10.20944/preprints202009.0086.v1

Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Molecular Pharming to Support Human Life on the Moon, Mars, and Beyond

Version 1 : Received: 3 September 2020 / Approved: 4 September 2020 / Online: 4 September 2020 (07:31:34 CEST)

How to cite: McNulty, M.J.; Xiong, Y.; Yates, K.; Karuppanan, K.; Hilzinger, J.M.; Berliner, A.J.; Delzio, J.; Arkin, A.P.; Lane, N.E.; Nandi, S.; McDonald, K.A. Molecular Pharming to Support Human Life on the Moon, Mars, and Beyond. Preprints 2020, 2020090086 (doi: 10.20944/preprints202009.0086.v1). McNulty, M.J.; Xiong, Y.; Yates, K.; Karuppanan, K.; Hilzinger, J.M.; Berliner, A.J.; Delzio, J.; Arkin, A.P.; Lane, N.E.; Nandi, S.; McDonald, K.A. Molecular Pharming to Support Human Life on the Moon, Mars, and Beyond. Preprints 2020, 2020090086 (doi: 10.20944/preprints202009.0086.v1).

Cite as:

McNulty, M.J.; Xiong, Y.; Yates, K.; Karuppanan, K.; Hilzinger, J.M.; Berliner, A.J.; Delzio, J.; Arkin, A.P.; Lane, N.E.; Nandi, S.; McDonald, K.A. Molecular Pharming to Support Human Life on the Moon, Mars, and Beyond. Preprints 2020, 2020090086 (doi: 10.20944/preprints202009.0086.v1). McNulty, M.J.; Xiong, Y.; Yates, K.; Karuppanan, K.; Hilzinger, J.M.; Berliner, A.J.; Delzio, J.; Arkin, A.P.; Lane, N.E.; Nandi, S.; McDonald, K.A. Molecular Pharming to Support Human Life on the Moon, Mars, and Beyond. Preprints 2020, 2020090086 (doi: 10.20944/preprints202009.0086.v1).

Abstract

Space missions have always assumed that the risk of spacecraft malfunction far outweighs the risk of human system failure. This assumption breaks down for longer duration exploration missions and exposes vulnerabilities in space medical system. Space agencies can no longer buy down the majority of human system risk through the crew member selection process and emergency re-supply or evacuation. No mature medical solutions exist to close the risk gap. With recent advances in biotechnology, there is promise in augmenting a space pharmacy with a biologically-based space foundry for on-demand manufacturing of high-value medical products. Here we review the challenges and opportunities of molecular pharming, the production of pharmaceuticals in plants, as the basis of a space medical foundry to close the risk gap in current space medical systems. Plants have long been considered an important life support object in space and can now also be viewed as programmable factories in space. Advances in molecular pharming-based space foundries will have widespread application in promoting simple and accessible pharmaceutical manufacturing on Earth.

Keywords

life support for space; plant molecular pharming

Subject

LIFE SCIENCES, Biotechnology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Download PDF Download Supplementary

Comments (0)

Your full name

Your affiliation information (e.g., name of your university/institution/organization)

Not displayed online.

Your Email address (not made public)

Importance: How significant is the paper to the field?

Outstanding/highlight paper

Significant contribution

Incremental contribution

No contribution

I am not qualified to judge

Soundness of evidence/arguments presented:

Conclusions well supported

Most conclusions supported (minor revision needed)

Incomplete evidence (major revision needed)

Hypothesis, unsupported conclusions, or proof-of-principle

I am not qualified to judge

Please leave your comment to this article below.

Mathematical equations can be typed in either LaTeX formats \\[ ... \\] or $$ ... $$, or MathML format <math> ... </math>. Try the LaTeX or MathML example.

Type equation:

Preview:

Copy equation into message below

Close menu

Please click a symbol to insert it into the message box below:

Please enter the link here:

Please enter a valid URL

Optionally, you can enter text that should appear as linked text:

Copy link into message below

Close menu

Please enter or paste the URL to the image here (please only use links to jpg/jpeg, png and gif images):

Please enter a valid URL

Copy image into message below

Close menu

Type author name or keywords to filter the list of references in this group (you can add a new citation under Bibliography):

No existing citations in Discussion Group

Wikify editor is a simple editor for wiki-style mark-up. It was written by MDPI for Sciforum in 2014. The rendering of the mark-up is based on Wiky.php with some tweaks. Rendering of mathematical equations is done with MathJax. Please send us a message for support or for reporting bugs.

Close menu

Please declare any conflicts of interest you may have with this paper, financial or otherwise.

I do not have a conflict of interest

I would like to declare a conflict of interest

Display my name on the website Send my name and email address to the authors I want to get recognition for my comment on Publons

[what’s this?]. Link your accounts here

Captcha

Renew

I accept the following conditions:

Comments must follow the standards of professional discourse and should focus on the scientific content of the article. Insulting or offensive language, personal attacks and off-topic remarks will not be permitted. Comments must be written in English. Preprints reserves the right to remove comments without notice. Readers who post comments are obliged to declare any competing interests, financial or otherwise.

We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.

Leave a public comment
Send a private comment to the author(s)

what’s this?

Add a record of this review to Publons to track and showcase your reviewing expertise across the world’s journals.

Downloads 0

Comments 0

Metrics 0

Get PDF Supplementary Files Cite Share 0

Bookmark BibSonomy Mendeley Reddit Delicious Publons

Alerts

Notify me about updates to this article or when a peer-reviewed version is published.

Preprints is a free preprint server supported by MDPI in Basel, Switzerland.

MDPI Initiatives

SciProfiles
Sciforum
Encyclopedia
MDPI Books
Scilit
Proceedings
JAMS

Important links

How it Works
Advisory Board
FAQ
Instructions for Authors
About

Choose the area that interest you and we will send you notifications of new preprints at your preferred frequency.

Disclaimer

We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.

RSS feed for

Preprints: The Multidisciplinary Preprint Platform

Paste the URL in your RSS reader:

https://www.preprints.org/rss

Please note that by using ScienceDirect RSS feeds, you agree to our Terms of Use and Privacy Policy.