Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

The Controversial Roles of Resveratrol in Mammalian Reproduction

Rolando Pasquariello
ORCID logo ,
Nicole Verdile
,
Tiziana A.L. Brevini
,
Fulvio Gandolfi
* ORCID logo ,
Cristiano Boiti
,
Massimo Zerani
* ORCID logo ,
Margherita Maranesi
ORCID logo
Version 1 : Received: 31 August 2020 / Approved: 1 September 2020 / Online: 1 September 2020 (09:55:01 CEST)

A peer-reviewed article of this Preprint also exists.

Pasquariello, R.; Verdile, N.; Brevini, T.A.L.; Gandolfi, F.; Boiti, C.; Zerani, M.; Maranesi, M. The Role of Resveratrol in Mammalian Reproduction. Molecules 2020, 25, 4554. Pasquariello, R.; Verdile, N.; Brevini, T.A.L.; Gandolfi, F.; Boiti, C.; Zerani, M.; Maranesi, M. The Role of Resveratrol in Mammalian Reproduction. Molecules 2020, 25, 4554.

Abstract

Resveratrol is one of the most investigated natural polyphenolic compounds and is contained in more than 70 types of plants and in red wine. The widespread interest in this polyphenol derives from its antioxidant, anti-inflammatory and anti-aging properties. Several studies have established that resveratrol regulates animal reproduction. However, the mechanisms of action and the potential therapeutic effects are still unclear. This review aims to clarify the role of resveratrol in the male and female reproductive functions, with a focus on animals of veterinary interest. In the female, resveratrol has been considered a phytoestrogen due to its capacity to modulate ovarian function and steroidogenesis via sirtuins, SIRT1, in particular. Resveratrol has also been used to enhance aged oocyte quality, and as a gametes cryo-protectant with mainly antioxidant, and anti-apoptotic effects. In the male, resveratrol enhanced testes function and spermatogenesis through activation of AMPK pathway. Furthermore, resveratrol has been supplemented to semen extenders improving the preservation of sperm quality. In conclusion, resveratrol has potentially beneficial effects for ameliorating ovarian and testes function. However, due to unclear data, further studies are necessary to consolidate these findings.

Keywords

polyphenols; reproduction; phytoestrogens; ovary function; sirtuin; testis function; spermatozoa; cryopreservation; sperm quality; oocyte quality

Subject

Biology and Life Sciences, Animal Science, Veterinary Science and Zoology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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