Version 1
: Received: 27 August 2020 / Approved: 30 August 2020 / Online: 30 August 2020 (10:59:17 CEST)
Version 2
: Received: 16 October 2020 / Approved: 16 October 2020 / Online: 16 October 2020 (12:11:04 CEST)
How to cite:
Li, Z.; Buck, M. Beyond History: The List of The Most Well Studied Human Protein Structures. Preprints2020, 2020080655. https://doi.org/10.20944/preprints202008.0655.v1
Li, Z.; Buck, M. Beyond History: The List of The Most Well Studied Human Protein Structures. Preprints 2020, 2020080655. https://doi.org/10.20944/preprints202008.0655.v1
Li, Z.; Buck, M. Beyond History: The List of The Most Well Studied Human Protein Structures. Preprints2020, 2020080655. https://doi.org/10.20944/preprints202008.0655.v1
APA Style
Li, Z., & Buck, M. (2020). Beyond History: The List of The Most Well Studied Human Protein Structures. Preprints. https://doi.org/10.20944/preprints202008.0655.v1
Chicago/Turabian Style
Li, Z. and Matthias Buck. 2020 "Beyond History: The List of The Most Well Studied Human Protein Structures" Preprints. https://doi.org/10.20944/preprints202008.0655.v1
Abstract
Of 20,000 or so canonical human protein sequences, as of July 2020, 6,747 proteins have had their full or partial medium to high-resolution structures determined by x-ray crystallography or other methods. Which of these proteins dominate the protein database (the PDB) and why? In this paper, we list the 272 top protein structures based on the number of their PDB depositions. This set of proteins accounts for more than 40% of all available human PDB entries and represent past trend and current status for protein science. We briefly discuss the relationship which some of the prominent protein structures have with protein biophysics research and mention their relevance to human diseases. The information may inspire researchers who are new to protein science, but it also provides a year 2020 snap-shot for the state of protein science.
Keywords
mostly studied human protein structure; human diseases; biophysics
Subject
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
