Working Paper Article Version 1 This version is not peer-reviewed

Atraric Acid Exhibits Anti-Inflammatory Effect in Lipopolysaccharide-Stimulated RAW264.7cells and Mouse Models

Version 1 : Received: 26 August 2020 / Approved: 27 August 2020 / Online: 27 August 2020 (12:10:17 CEST)

How to cite: Mun, S.; Kang, K.; Jang, H.; Hwang, Y.; Hong, S.; Kim, S.; Cho, H.; Hur, J.; Yee, S. Atraric Acid Exhibits Anti-Inflammatory Effect in Lipopolysaccharide-Stimulated RAW264.7cells and Mouse Models. Preprints 2020, 2020080615 Mun, S.; Kang, K.; Jang, H.; Hwang, Y.; Hong, S.; Kim, S.; Cho, H.; Hur, J.; Yee, S. Atraric Acid Exhibits Anti-Inflammatory Effect in Lipopolysaccharide-Stimulated RAW264.7cells and Mouse Models. Preprints 2020, 2020080615

Abstract

As symbionts of fungi and algae, lichens produce a variety of secondary products which pharmacological activities. This study aimed to investigate the anti-inflammatory activities of Heterodermia hypoleuca and its main compound, atraric acid. The results confirmed that atraric acid could regulating induced pro-inflammatory cytokine, nitric oxide, induced nitric oxide synthase and cyclooxygenase-2 expression by lipopolysaccharide (LPS)-stimulated RAW264.7 cells. Means while, atraric acid down-regulated expression of phosphorylated IκB, ERK and nuclear factor kappa B (NFκB) signaling pathway to exhibit anti-inflammatory effects in LPS-stimulated RAW264.7 cells. Based on these results, the anti-inflammatory effect of atraric acid during LPS-induced endotoxin shock in a mouse model was confirmed. In the atraric acid treated-group, cytokine production was decreased in the peritoneum and serum, and each organ damaged by LPS-stimulation was recovered. These results show that atraric acid has an anti-inflammatory effect and its molecular mechanism may be involved in the inactivation of the ERK/NFκB signaling pathway, demonstrating its value as a potential therapeutic for inflammatory diseases.

Subject Areas

Anti-inflammation; Endotoxin shock; Atraric acid; Lichen; Heterodermia hypoleuca

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