Preprint Hypothesis Version 2 Preserved in Portico This version is not peer-reviewed

On Catalysis by Biological Macromolecular Enzymes

Version 1 : Received: 26 August 2020 / Approved: 27 August 2020 / Online: 27 August 2020 (09:04:44 CEST)
Version 2 : Received: 9 November 2020 / Approved: 16 November 2020 / Online: 16 November 2020 (08:28:55 CET)

A peer-reviewed article of this Preprint also exists.

Dong J. On Catalytic Kinetics of Enzymes. Processes. 2021; 9(2):271. Dong J. On Catalytic Kinetics of Enzymes. Processes. 2021; 9(2):271.


Classical enzyme kinetics are summarized and linked with modern discoveries here. The time course of sequential catalytic events by biological macromolecular enzyme is analyzed at the molecular level; the relationships between catalytic efficiency (turnover number), catalytic rate/velocity, the amount of time taken and physical/biochemical conditions of the system are discussed. This writing tries to connect the microscopic molecular behavior of enzyme to kinetic data obtained in experiment, and the hypothesis proposed here provide an interpretation to previous experimental observations and can be testified by future experiments.


catalysis; kinetics; time; biological macromolecular enzyme; large biological macro-substrate; catalytic step; catalytic efficiency; turnover number


Biology and Life Sciences, Biochemistry and Molecular Biology

Comments (1)

Comment 1
Received: 16 November 2020
Commenter: Jianshu Dong
Commenter's Conflict of Interests: Author
Comment: This version has been revised.
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