Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

The Association Between Presence of Comorbidities and COVID-19 Severity; A Systematic Review and Meta-Analysis

Version 1 : Received: 20 August 2020 / Approved: 21 August 2020 / Online: 21 August 2020 (07:47:44 CEST)

A peer-reviewed article of this Preprint also exists.

Journal reference: Cerebrovascular Diseases 2021
DOI: 10.1159/000513288


Results: A total of 6270 individuals were assessed (1615 severe and 4655 non-severe patients). The median age was 63 (95% CI: 49-74) and 47 (95% CI: 19-63) years in the severe and non-severe groups, respectively. Moreover, about 41% of patients had comorbidities. Severity was higher in patients with history of cerebrovascular disease: OR 4.85 (95% CI: 3.11-7.57). The odds of being in severe group increase by 4.81(95% CI: 3.43-6.74) for history of cardiovascular disease (CVD). This was 4.19 (95% CI: 2.84-6.19) for chronic lung disease and 3.18, 95% CI: 2.09-4.82 for cancer .The odds ratio of a diabetes and hypertension were 2.61 (95% CI: 2.02-3.3), and 2.37( 95% CI: 1.80-3.13) respectively.


COVID-19; disease severity; comorbid conditions


MEDICINE & PHARMACOLOGY, General Medical Research

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