Version 1
: Received: 19 August 2020 / Approved: 21 August 2020 / Online: 21 August 2020 (03:39:15 CEST)
How to cite:
Hare, J.; Fiore-Gartland, A.; McGowan, E.; Rosenthal, R.; Hunter, E.; Gilmour, J.; Nielsen, M. Selective HLA Restriction Permits the Evaluation and Interpretation of Immunogenic Breadth at Comparable Levels to Autologous HLA. Preprints2020, 2020080467 (doi: 10.20944/preprints202008.0467.v1).
Hare, J.; Fiore-Gartland, A.; McGowan, E.; Rosenthal, R.; Hunter, E.; Gilmour, J.; Nielsen, M. Selective HLA Restriction Permits the Evaluation and Interpretation of Immunogenic Breadth at Comparable Levels to Autologous HLA. Preprints 2020, 2020080467 (doi: 10.20944/preprints202008.0467.v1).
Cite as:
Hare, J.; Fiore-Gartland, A.; McGowan, E.; Rosenthal, R.; Hunter, E.; Gilmour, J.; Nielsen, M. Selective HLA Restriction Permits the Evaluation and Interpretation of Immunogenic Breadth at Comparable Levels to Autologous HLA. Preprints2020, 2020080467 (doi: 10.20944/preprints202008.0467.v1).
Hare, J.; Fiore-Gartland, A.; McGowan, E.; Rosenthal, R.; Hunter, E.; Gilmour, J.; Nielsen, M. Selective HLA Restriction Permits the Evaluation and Interpretation of Immunogenic Breadth at Comparable Levels to Autologous HLA. Preprints 2020, 2020080467 (doi: 10.20944/preprints202008.0467.v1).
Abstract
Existing approaches to identifying predictive T-cell epitopes have traditionally utilized either 2-digit HLA super-families or more commonly autologous HLA alleles to facilitate the predictions, but frequently they may not consider their representation within a population. Here we propose a modification to this concept whereby subsets of individuals are selected for their specific HLA allele profiles and the representation they provide within a given population. Using this targeted approach to HLA selection and the linkages to specific individuals may enable the design of restricted experimental strategies.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
