Version 1
: Received: 19 August 2020 / Approved: 21 August 2020 / Online: 21 August 2020 (03:39:15 CEST)
How to cite:
Hare, J.; Fiore-Gartland, A.; McGowan, E.; Rosenthal, R.; Hunter, E.; Gilmour, J.; Nielsen, M. Selective HLA Restriction Permits the Evaluation and Interpretation of Immunogenic Breadth at Comparable Levels to Autologous HLA. Preprints2020, 2020080467 (doi: 10.20944/preprints202008.0467.v1).
Hare, J.; Fiore-Gartland, A.; McGowan, E.; Rosenthal, R.; Hunter, E.; Gilmour, J.; Nielsen, M. Selective HLA Restriction Permits the Evaluation and Interpretation of Immunogenic Breadth at Comparable Levels to Autologous HLA. Preprints 2020, 2020080467 (doi: 10.20944/preprints202008.0467.v1).
Cite as:
Hare, J.; Fiore-Gartland, A.; McGowan, E.; Rosenthal, R.; Hunter, E.; Gilmour, J.; Nielsen, M. Selective HLA Restriction Permits the Evaluation and Interpretation of Immunogenic Breadth at Comparable Levels to Autologous HLA. Preprints2020, 2020080467 (doi: 10.20944/preprints202008.0467.v1).
Hare, J.; Fiore-Gartland, A.; McGowan, E.; Rosenthal, R.; Hunter, E.; Gilmour, J.; Nielsen, M. Selective HLA Restriction Permits the Evaluation and Interpretation of Immunogenic Breadth at Comparable Levels to Autologous HLA. Preprints 2020, 2020080467 (doi: 10.20944/preprints202008.0467.v1).
Abstract
Existing approaches to identifying predictive T-cell epitopes have traditionally utilized either 2-digit HLA super-families or more commonly autologous HLA alleles to facilitate the predictions, but frequently they may not consider their representation within a population. Here we propose a modification to this concept whereby subsets of individuals are selected for their specific HLA allele profiles and the representation they provide within a given population. Using this targeted approach to HLA selection and the linkages to specific individuals may enable the design of restricted experimental strategies.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Jonathan Hare
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