Preprint Technical Note Version 1 Preserved in Portico This version is not peer-reviewed

Selective HLA Restriction Permits the Evaluation and Interpretation of Immunogenic Breadth at Comparable Levels to Autologous HLA

Version 1 : Received: 19 August 2020 / Approved: 21 August 2020 / Online: 21 August 2020 (03:39:15 CEST)

How to cite: Hare, J.; Fiore-Gartland, A.; McGowan, E.; Rosenthal, R.; Hunter, E.; Gilmour, J.; Nielsen, M. Selective HLA Restriction Permits the Evaluation and Interpretation of Immunogenic Breadth at Comparable Levels to Autologous HLA. Preprints 2020, 2020080467 (doi: 10.20944/preprints202008.0467.v1). Hare, J.; Fiore-Gartland, A.; McGowan, E.; Rosenthal, R.; Hunter, E.; Gilmour, J.; Nielsen, M. Selective HLA Restriction Permits the Evaluation and Interpretation of Immunogenic Breadth at Comparable Levels to Autologous HLA. Preprints 2020, 2020080467 (doi: 10.20944/preprints202008.0467.v1).

Abstract

Existing approaches to identifying predictive T-cell epitopes have traditionally utilized either 2-digit HLA super-families or more commonly autologous HLA alleles to facilitate the predictions, but frequently they may not consider their representation within a population. Here we propose a modification to this concept whereby subsets of individuals are selected for their specific HLA allele profiles and the representation they provide within a given population. Using this targeted approach to HLA selection and the linkages to specific individuals may enable the design of restricted experimental strategies.

Subject Areas

HLA diversity; HLA frequency; predicted T-cell epitopes; immunogenic breath

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