Preprint Concept Paper Version 1 Preserved in Portico This version is not peer-reviewed

The Molecular Interactome of the Centriole, Cell Cycle and Ciliary Proteins Modulates Cell Mass Growth and Structural Organization During Development in Metazoans

Version 1 : Received: 19 August 2020 / Approved: 20 August 2020 / Online: 20 August 2020 (09:49:27 CEST)

How to cite: OJ, R.; ., A.; Chakraborty, S.; Kateriya, S.; Veleri, S. The Molecular Interactome of the Centriole, Cell Cycle and Ciliary Proteins Modulates Cell Mass Growth and Structural Organization During Development in Metazoans. Preprints 2020, 2020080451 (doi: 10.20944/preprints202008.0451.v1). OJ, R.; ., A.; Chakraborty, S.; Kateriya, S.; Veleri, S. The Molecular Interactome of the Centriole, Cell Cycle and Ciliary Proteins Modulates Cell Mass Growth and Structural Organization During Development in Metazoans. Preprints 2020, 2020080451 (doi: 10.20944/preprints202008.0451.v1).

Abstract

Metazoans have an elaborate and functionally segmented body. It evolves from a single cell by systematic divisions. Metazoans attain structural complexity with exquisite precision, which is a molecular mystery. The indispensable role of centrioles in cell division and ciliogenesis can shed insight into this riddle. Cell division helps in growth of the body and is a highly regulated and integrated process. Its errors cause malignancies. The cell mass is organized during organogenesis. Prior to it, the centrioles are retrieved from the cell cycle to initiate ciliogenesis. The cilia-modulated developmental signaling pathways elaborate the body plan. The secluded compartment of the cilium reduces noise during signaling and is essential for a precise body plan development. The dysfunctional centrioles and cilia can distort body plan. Thus, centriole has a dual role in growth and cellular organization. This concept review analyses the comprehensive interactome and the key domain features (like C2 domain) of molecules which connect and disarm the centriole from the cell cycle and ciliogenesis by switching on or off the essential regulators of the pathways. The concentration of these signaling pathways at the centriole reinforces the hypothesis that centriole is the molecular workstation to carve out structural design and complexity in metazoans.

Subject Areas

Metazoa; body plan; developmental pathways; limb development; Shh; centriole; cell division; cilia; centriole gene expression

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our diversity statement.

Leave a public comment
Send a private comment to the author(s)
Views 0
Downloads 0
Comments 0
Metrics 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.