Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Epidemiological Characteristics and Survival in Patients with de novo Metastatic Prostate Cancer.

Version 1 : Received: 2 August 2020 / Approved: 5 August 2020 / Online: 5 August 2020 (09:46:50 CEST)

How to cite: Cattrini, C.; Soldato, D.; Rubagotti, A.; Zinoli, L.; Zanardi, E.; Barboro, P.; Messina, C.; Castro, E.; Olmos, D.; Boccardo, F. Epidemiological Characteristics and Survival in Patients with de novo Metastatic Prostate Cancer.. Preprints 2020, 2020080117 (doi: 10.20944/preprints202008.0117.v1). Cattrini, C.; Soldato, D.; Rubagotti, A.; Zinoli, L.; Zanardi, E.; Barboro, P.; Messina, C.; Castro, E.; Olmos, D.; Boccardo, F. Epidemiological Characteristics and Survival in Patients with de novo Metastatic Prostate Cancer.. Preprints 2020, 2020080117 (doi: 10.20944/preprints202008.0117.v1).

Abstract

The real-world outcomes of patients with metastatic prostate cancer (mPCa) are largely unexplored. We investigated the improvements in overall survival (OS) and cancer-specific survival (CSS) in patients with de novo mPCa in latest years. The USA SEER Research Data (2000-2017) were analyzed using the SEER*Stat software. The Kaplan-Meier method and Cox regression were used. Patients with de novo mPCa were allocated to 3 cohorts based on year of diagnosis: A (2000-2003), B (2004-2010), C (2011-2014). Maximum follow-up was fixed to 5 years. Overall, 26434 patients were included. Age, race and metastatic stage significantly affected OS and CSS. After adjustment for age and race, patients in cohort C showed 9% reduced risk of death (HR:0.91 [95% CI, 0.87-0.95], p<0.001) and 8% reduced risk of cancer-specific death (HR:0.91 [95% CI, 0.87-0.95], p<0.001) compared to those in cohort A. After adjustment for age, race and metastatic stage, patients in cohort C showed an improvement in OS and CSS compared to cohort B (HR:0.94 [95% CI, 0.91-0.97], p=0.001 and HR:0.89 [95% CI, 0.85-0.92], p<0.001). Patients with M1c disease had a more pronounced improvement in OS and CSS compared with the other stages. No differences were found between cohort B and C. In conclusion, the prognosis of de novo mPCa remains poor with a median OS of 30 months and a median CSS of 35 months. Limited OS and CSS improvements were observed in latest years.

Subject Areas

prostatic neoplasms/mortality; prostatic neoplasms/epidemiology; SEER program

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