Measuring and Modelling the Epithelial Mesenchymal Hybrid State in Cancer: Clinical Implications

Mohit Kumar Jolly; Ryan J. Murphy; Sugandha Bhatia; Holly J. Whitfield; Melissa J. Davis; Erik W. Thompson

doi:10.20944/preprints202008.0023.v1

Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Version 1 : Received: 31 July 2020 / Approved: 2 August 2020 / Online: 2 August 2020 (12:07:34 CEST)
Version 2 : Received: 10 February 2021 / Approved: 10 February 2021 / Online: 10 February 2021 (15:04:19 CET)

The epithelial-mesenchymal (E/M) hybrid state has emerged as an important mediator of the elements of cancer progression facilitated by epithelial mesenchymal plasticity (EMP). We review here the evidence for the presence and prognostic potential of E/M hybrid state in carcinoma, modelling predictions and validations studies to demonstrate stabilised E/M hybrid intermediates along the spectrum of EMP, and computational approaches for characterising and quantifying EMP phenotypes, with particular attention to the emerging realm of single-cell approaches through RNA sequencing and protein-based approaches.

epithelial mesenchymal plasticity (EMP); epithelial mesenchymal transition (EMT); mesenchymal epithelial transition (MET); E/M Hybrid; partial EMT; computational biology; mathematical modeling; cancer

Biology and Life Sciences, Anatomy and Physiology

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Measuring and Modelling the Epithelial Mesenchymal Hybrid State in Cancer: Clinical Implications

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