Chen, L.; Dong, Y.; Li, J.; Wang, D.; Xu, L.; Zhao, J.; Liu, H.; Lu, J.; Yao, Z.; Li, X. The Genomic Distribution Map of Human Papillomavirus in China. Preprints2020, 2020080002
APA Style
Chen, L., Dong, Y., Li, J., Wang, D., Xu, L., Zhao, J., Liu, H., Lu, J., Yao, Z., & Li, X. (2020). The Genomic Distribution Map of Human Papillomavirus in China. Preprints. https://doi.org/
Chicago/Turabian Style
Chen, L., Zuoyi Yao and Xiaosong Li. 2020 "The Genomic Distribution Map of Human Papillomavirus in China" Preprints. https://doi.org/
Abstract
Background: Human papillomavirus (HPV) infection plays a key role in the development of cervical cancer that ranks as the third most common gynecological cancer in China. We attempt to investigate the age and genotype-specific prevalence of HPV DNA in western Chinese females. Methods: A total of 301,880 woman were recruited from 4 different regions of western China. Routine cervical samples were collected and HPV screening was performed using 21 HPV Genotyping test (Hybribio). The overall prevalence, age-specific prevalence, and genotype distribution were analyzed. Results: The overall prevalence of HPV was 18.01%. The high-risk HPV infection rate was 79.14%, the low-risk HPV infection rate was 12.56%, and the mixed HPV infection rate was 8.30%. The most common 4 HR HPV subtypes were HPV-52, 16, 58 and 53, which accounted for 20.49 %, 19.93 %, 14.54 % and 10.01 %. In LR HPV genotype, HPV-6 ranked the highest (28.17 %), followed by HPV-81 (9.09 %), HPV-11 (3.78 %). HPV genotype subgroup analysis also showed that single-type infections had the highest prevalence rate (77.26%) among HPV positive individuals. Among muti-infection genotype, double infection was most common with frequencies of 76.04%. Conclusion: This large report shows that the overall prevalence of HPV was high in China, whose distribution exhibits different patterns across different particular age and regions. Viral genotypes HPV53, 6 were are frequently detected in this population, which is worth of significant clinical attention.
Keywords
Human papillomavirus (HPV); cervical cancer; prevalence; genotypes; China
Subject
Medicine and Pharmacology, Pathology and Pathobiology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
