Working Paper Article Version 1 This version is not peer-reviewed

The Genomic Distribution Map of Human Papillomavirus in China

Version 1 : Received: 30 July 2020 / Approved: 1 August 2020 / Online: 1 August 2020 (16:25:46 CEST)

How to cite: Chen, L.; Dong, Y.; Li, J.; Wang, D.; Xu, L.; Zhao, J.; Liu, H.; Lu, J.; Yao, Z.; Li, X. The Genomic Distribution Map of Human Papillomavirus in China. Preprints 2020, 2020080002 Chen, L.; Dong, Y.; Li, J.; Wang, D.; Xu, L.; Zhao, J.; Liu, H.; Lu, J.; Yao, Z.; Li, X. The Genomic Distribution Map of Human Papillomavirus in China. Preprints 2020, 2020080002

Abstract

Background: Human papillomavirus (HPV) infection plays a key role in the development of cervical cancer that ranks as the third most common gynecological cancer in China. We attempt to investigate the age and genotype-specific prevalence of HPV DNA in western Chinese females. Methods: A total of 301,880 woman were recruited from 4 different regions of western China. Routine cervical samples were collected and HPV screening was performed using 21 HPV Genotyping test (Hybribio). The overall prevalence, age-specific prevalence, and genotype distribution were analyzed. Results: The overall prevalence of HPV was 18.01%. The high-risk HPV infection rate was 79.14%, the low-risk HPV infection rate was 12.56%, and the mixed HPV infection rate was 8.30%. The most common 4 HR HPV subtypes were HPV-52, 16, 58 and 53, which accounted for 20.49 %, 19.93 %, 14.54 % and 10.01 %. In LR HPV genotype, HPV-6 ranked the highest (28.17 %), followed by HPV-81 (9.09 %), HPV-11 (3.78 %). HPV genotype subgroup analysis also showed that single-type infections had the highest prevalence rate (77.26%) among HPV positive individuals. Among muti-infection genotype, double infection was most common with frequencies of 76.04%. Conclusion: This large report shows that the overall prevalence of HPV was high in China, whose distribution exhibits different patterns across different particular age and regions. Viral genotypes HPV53, 6 were are frequently detected in this population, which is worth of significant clinical attention.

Subject Areas

Human papillomavirus (HPV); cervical cancer; prevalence; genotypes; China

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