Self-adaptive Biosystems Through Tunable Genetic Parts and Circuits

Vittorio Bartoli; Mario di Bernardo; Thomas E. Gorochowski

doi:10.20944/preprints202007.0751.v2

Preprint Review Version 2 Preserved in Portico This version is not peer-reviewed

Version 1 : Received: 30 July 2020 / Approved: 31 July 2020 / Online: 31 July 2020 (13:53:05 CEST)
Version 2 : Received: 6 October 2020 / Approved: 6 October 2020 / Online: 6 October 2020 (13:32:00 CEST)

Biological systems often need to operate in complex environments where conditions can rapidly change. This is possible due to their inherent ability to sense changes and adapt their behavior in response. Here, we detail recent advances in the creation of synthetic genetic parts and circuits whose behaviors can be dynamically tuned through a variety of intra- and extra-cellular signals. We show how this capability lays the foundation for implementing control engineering schemes in living cells and allows for the creation of biological systems that are able to self-adapt, ensuring their functionality is maintained in the face of varying environmental and physiological conditions. We end by discussing some of the broader implications of this technology for the safe deployment of synthetic biology.

tunable; genetic part; control; adaptation; cybergenetics; synthetic biology; systems biology

Comment 1

Received: 6 October 2020
Commenter: Thomas Gorochowski
Commenter's Conflict of Interests: Author

Comment: Minor edits to improve readability.

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Self-adaptive Biosystems Through Tunable Genetic Parts and Circuits

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