Preprint Review Version 1 This version is not peer-reviewed

Self-adaptive Biosystems Through Tunable Genetic Parts and Circuits

Version 1 : Received: 30 July 2020 / Approved: 31 July 2020 / Online: 31 July 2020 (13:53:05 CEST)

How to cite: Bartoli, V.; di Bernardo, M.; Gorochowski, T.E. Self-adaptive Biosystems Through Tunable Genetic Parts and Circuits. Preprints 2020, 2020070751 (doi: 10.20944/preprints202007.0751.v1). Bartoli, V.; di Bernardo, M.; Gorochowski, T.E. Self-adaptive Biosystems Through Tunable Genetic Parts and Circuits. Preprints 2020, 2020070751 (doi: 10.20944/preprints202007.0751.v1).

Abstract

Biological systems often need to operate in complex environments where conditions can rapidly change. This is possible due to their inherent ability to sense changes and adapt by adjusting their behavior in response. Here, we detail recent advances in the creation of synthetic genetic parts and circuits whose behaviors can be dynamically tuned through a variety of intra- and extra-cellular signals. We show how this capability lays the foundation for implementing control engineering schemes in living cells and allows for the creation of biological systems that are able to self-adapt, ensuring their functionality is maintained in the face of varying environmental and physiological conditions. We end by discussing some of the broader implications of this technology for the safe deployment of synthetic biology.

Subject Areas

tunable; genetic part; control; adaptation; cybergenetics; synthetic biology; systems biology

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