Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Fatal Interstitial Pneumonia Caused by Bovine Coronavirus in Cows from Southern Italy

Version 1 : Received: 30 July 2020 / Approved: 31 July 2020 / Online: 31 July 2020 (13:46:21 CEST)

How to cite: Amoroso, M.G.; Lucifora, G.; Degli Uberti, B.; Serra, F.; Di Domenico, A.; Cuomo, M.C.; De Luca, G.; Bove, F.; Galiero, G.; Fusco, G. Fatal Interstitial Pneumonia Caused by Bovine Coronavirus in Cows from Southern Italy. Preprints 2020, 2020070749 (doi: 10.20944/preprints202007.0749.v1). Amoroso, M.G.; Lucifora, G.; Degli Uberti, B.; Serra, F.; Di Domenico, A.; Cuomo, M.C.; De Luca, G.; Bove, F.; Galiero, G.; Fusco, G. Fatal Interstitial Pneumonia Caused by Bovine Coronavirus in Cows from Southern Italy. Preprints 2020, 2020070749 (doi: 10.20944/preprints202007.0749.v1).

Abstract

An outbreak of winter disease, complicated by severe respiratory syndrome, occurred in January 2020 in a high production dairy cow herd located in a hilly area of the Calabria region. Of the 52 animals belonging to the farm, 5 (9.6%) died with severe respiratory distress, death occurring 3-4 days after the appearance of the respiratory signs (caught and gasping breath). Microbiological analysis revealed absence of pathogenic bacteria whilst Real-time PCR identified the presence of RNA from Bovine Coronavirus (BCoV) in several organs: lungs, small intestine (jejunum), mediastinal lymph nodes, liver and placenta. Since being the only pathogen identified, BCoV was hypothesized to be the cause of the lethal pulmonary infection. Like the other CoVs, BCoV is able to cause different syndromes. Its role in calfhood diarrhoea and in mild respiratory disease is well known: we report instead the involvement of this virus in a severe and fatal respiratory disorder, with symptoms and disease evolution resembling that of Severe Acute Respiratory Syndromes (SARS).

Subject Areas

Bovine coronavirus; intersititial pneumonia; phylogenetic analysis; Real time PCR

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