Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

OVOL1/2: Drivers of Epithelial Differentiation in Development, Disease and Reprogramming

Version 1 : Received: 28 July 2020 / Approved: 30 July 2020 / Online: 30 July 2020 (10:21:43 CEST)

How to cite: Saxena, K.; Srikrishnan, S.; Celia-Terrassa, T.; Jolly, M.K. OVOL1/2: Drivers of Epithelial Differentiation in Development, Disease and Reprogramming. Preprints 2020, 2020070713 (doi: 10.20944/preprints202007.0713.v1). Saxena, K.; Srikrishnan, S.; Celia-Terrassa, T.; Jolly, M.K. OVOL1/2: Drivers of Epithelial Differentiation in Development, Disease and Reprogramming. Preprints 2020, 2020070713 (doi: 10.20944/preprints202007.0713.v1).

Abstract

OVOL proteins (OVOL1 and OVOL2), vertebrate homologs of Drosophila OVO, are critical regulators of epithelial lineage determination and differentiation during embryonic development in tissues such as kidney, skin, mammary epithelia, testis. OVOL inhibits EMT and can promote MET; moreover, they can regulate the stemness of cancer cells, thus playing an important role during cancer cell metastasis. Due to their central role in differentiation and maintenance of epithelial lineage, OVOL overexpression has been shown to be capable of reprogramming fibroblasts to epithelial cells. Here, we review the roles of OVOL mediated epithelial differentiation across multiple contexts – embryonic development, cancer progression, and cellular reprogramming.

Subject Areas

Mesenchymal Epithelial Transition; Cellular Reprogramming; OVOL1; OVOL2; Epithelial Mesenchymal Transition

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