Preprint Brief Report Version 1 Preserved in Portico This version is not peer-reviewed

Can Ventilatory Strategies in COVID-19 Have an Impact on Outcomes?

Peter Sherren
* ,
Luigi Camporota
,
Barnaby Sanderson
,
Andrew Jones
,
Manu Shankar-Hari
,
Chris Meadows
,
Nicholas Barrett
,
Marlies Ostermann
,
Nicholas Hart
Version 1 : Received: 22 July 2020 / Approved: 24 July 2020 / Online: 24 July 2020 (04:44:14 CEST)

How to cite: Sherren, P.; Camporota, L.; Sanderson, B.; Jones, A.; Shankar-Hari, M.; Meadows, C.; Barrett, N.; Ostermann, M.; Hart, N. Can Ventilatory Strategies in COVID-19 Have an Impact on Outcomes? . Preprints 2020, 2020070569. https://doi.org/10.20944/preprints202007.0569.v1 Sherren, P.; Camporota, L.; Sanderson, B.; Jones, A.; Shankar-Hari, M.; Meadows, C.; Barrett, N.; Ostermann, M.; Hart, N. Can Ventilatory Strategies in COVID-19 Have an Impact on Outcomes? . Preprints 2020, 2020070569. https://doi.org/10.20944/preprints202007.0569.v1

Abstract

The rapidly evolving understanding of Coronavirus Disease 2019 (COVID-19) respiratory failure pathogenesis, limited disease-specific evidence and demand-resource imbalances have posed significant challenges for intensive care clinicians. In this single-centre retrospective cohort study we describe the outcomes of COVID-19 patients admitted to Guy’s and St. Thomas’ NHS Foundation Trust (GSTT) critical care service. Patients were managed according to a local respiratory failure management pathway that was predicated on timely invasive ventilation when indicated and tailored ventilatory strategies according to pulmonary mechanics. Between 2nd March and 25th May 2020 GSTT critical care service admitted 316 patients with confirmed COVID-19. Of the 201 patients admitted directly through the Emergency Department with a completed critical care outcome, 71.1% survived to critical care discharge. These favourable outcomes may serve to inform the wider debate on the optimal ventilatory management in COVID-19.

Keywords

SARS-CoV-2; COVID-19; respiratory failure; ARDS; ventilation; ECMO

Subject

Medicine and Pharmacology, Immunology and Allergy

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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