Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

COVID-19 Related Organ Dysfunction and Management Strategies on the Intensive Care Unit

Version 1 : Received: 22 July 2020 / Approved: 24 July 2020 / Online: 24 July 2020 (04:00:50 CEST)

A peer-reviewed article of this Preprint also exists.

Journal reference: British Journal of Anaesthesia 2020
DOI: 10.1016/j.bja.2020.08.050

Abstract

The Coronavirus Disease 2019 (COVID-19) pandemic has resulted in a significant surge of critically ill patients and an unprecedented demand on intensive care services. The rapidly evolving understanding of pathogenesis, limited disease specific evidence and demand-resource imbalances have posed significant challenges for intensive care clinicians. COVID-19 is a complex multisystem inflammatory vasculopathy with a significant mortality implication for those admitted to intensive care. Institutional strategic preparation and meticulous intensive care support are essential to maximising outcomes during the pandemic. The significant mortality variation observed between institutions and internationally, despite a single aetiology and uniform presentation, highlights the potential influence of management strategies on outcome. Given that optimal organ support and adjunctive therapies for COVID-19 have not yet been well defined by trial-based outcomes, strategies are predicated on existing literature and experiential learning. This review outlines the relevant pathophysiology and management strategies for critically ill patients with COVID-19, and shares some of the collective learning accumulated in a high volume Severe Respiratory Failure centre in London.

Subject Areas

SARS-CoV-2; COVID-19; respiratory failure; ARDS; ventilation; MODS; ECMO

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our diversity statement.

Leave a public comment
Send a private comment to the author(s)
Views 0
Downloads 0
Comments 0
Metrics 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.