Preprint Article Version 1 This version is not peer-reviewed

Fatty Liver, and Not Visceral Fat, is More Associated with Liver Fibrosis and Diabetes in Non-obese Japanese Individuals: A Cross-sectional Study

Version 1 : Received: 22 July 2020 / Approved: 23 July 2020 / Online: 23 July 2020 (09:38:15 CEST)

How to cite: Urata, N.; Kawanaka, M.; Nishino, K.; Ishii, K.; Tanikawa, T.; Suehiro, M.; Sasai, T.; Haruma, K.; Kawamoto, H.; Nakamura, J.; Manabe, N.; Kamada, T. Fatty Liver, and Not Visceral Fat, is More Associated with Liver Fibrosis and Diabetes in Non-obese Japanese Individuals: A Cross-sectional Study. Preprints 2020, 2020070543 (doi: 10.20944/preprints202007.0543.v1). Urata, N.; Kawanaka, M.; Nishino, K.; Ishii, K.; Tanikawa, T.; Suehiro, M.; Sasai, T.; Haruma, K.; Kawamoto, H.; Nakamura, J.; Manabe, N.; Kamada, T. Fatty Liver, and Not Visceral Fat, is More Associated with Liver Fibrosis and Diabetes in Non-obese Japanese Individuals: A Cross-sectional Study. Preprints 2020, 2020070543 (doi: 10.20944/preprints202007.0543.v1).

Abstract

Asians are known to more likely than Westerners develop fatty liver and lifestyle-related diseases despite their weight. However, the relationship between fat accumulation and lifestyle-related diseases in non-obese Asians is unknown. Therefore, this study aimed to analyze visceral fat and hepatic fat in participants with a normal body mass index (BMI) and examine their characteristics during a medical checkup. This cross-sectional study was conducted on 663 of 1,142 patients who underwent abdominal ultrasonography and who had an alcohol intake (converted to ethanol) of <30 g/day for males and <20 g/day for females and a BMI of <25 kg/m2 during a health checkup. Participants were classified into four groups: group A, visceral fat accumulation (VFA) (−) and fatty liver (FL) (−) (n = 549); group B, VFA (+) and FL(−) (n = 32); group C, VFA (−) and FL (+) (n = 58); and group D, VFA (+) and FL (+) (n = 24). The frequencies of lifestyle-related disease complications, liver function tests, and liver fibrosis were evaluated among the four groups. Compared with group A (control), groups B, C, and D had higher number of males; BMI; abdominal circumference, ALT, AST, γ-GTP, triglyceride, uric acid, fasting blood sugar levels; and incidence of hyperlipidemia. Groups C and D had higher ALT, HbA1c, cholinesterase, and triglyceride levels; FIB4 index; and number of patients with diabetes mellitus (DM) than groups A and B; however, there was no difference between groups A and B. FL is a risk factor of DM and liver fibrosis in non-obese Japanese individuals; however, VFA only is not a risk factor of DM and liver fibrosis.

Subject Areas

nonalcoholic fatty liver disease; lean nonalcoholic fatty liver disease; visceral fat; non-obese; fatty liver; insulin resistance

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