Preprint Review Version 1 This version is not peer-reviewed

Pursuing the Elixir of Life: In Vivo Antioxidative Effect of Manganosalen Complexes, a Review

Version 1 : Received: 10 July 2020 / Approved: 11 July 2020 / Online: 11 July 2020 (03:30:41 CEST)

How to cite: Rouco, L.; Gonzalez-Noya, A.M.; Pedrido, R.; Maneiro, M. Pursuing the Elixir of Life: In Vivo Antioxidative Effect of Manganosalen Complexes, a Review. Preprints 2020, 2020070222 (doi: 10.20944/preprints202007.0222.v1). Rouco, L.; Gonzalez-Noya, A.M.; Pedrido, R.; Maneiro, M. Pursuing the Elixir of Life: In Vivo Antioxidative Effect of Manganosalen Complexes, a Review. Preprints 2020, 2020070222 (doi: 10.20944/preprints202007.0222.v1).

Abstract

Manganosalen complexes are coordination compounds that possess a chelating salen-type ligand, a class of bis-Schiff bases obtained by condensation of salicylaldehyde and a diamine. They may act as catalytic antioxidants mimicking both the structure and the reactivity of the native antioxidant enzymes active site. Thus, manganosalen complexes have shown to exhibit superoxide dismutase, catalase, and glutathione peroxidase activities, and they could potentially facilitate the scavenging of excess ROS, thereby restoring the redox balance in the damaged cells and organs. Initial catalytic studies compared the potency of these compounds as antioxidants in terms of rate constants of the chemical reactivity against ROS, giving catalytic values approaching and even exceeding that of the native antioxidative enzymes. Although most of these catalytic studies lack of biological relevance, subsequent in vitro studies have confirmed the efficiency of many manganosalen complexes in oxidative stress models. These synthetic catalytic scavengers, cheaper than natural antioxidants, have accordingly attracted intensive attention for the therapy of ROS-mediated injuries. The aim of this review is to focus on in vivo studies performed on manganosalen complexes and their activity on the treatment of several pathological disorders associated with oxidative damage. This disorders, ranging from the prevention of fetal malformations to the extension of lifespan, include neurodegenerative, inflammatory and cardiovascular diseases, tissue injury, and other damages related to liver, kidney or lungs.

Subject Areas

ROS; oxidative stress; catalytic antioxidants; superoxide dismutase; catalase; peroxidase; manganese; salen-type ligands; animal studies

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our diversity statement.

Leave a public comment
Send a private comment to the author(s)
Views 0
Downloads 0
Comments 0
Metrics 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.