Version 1
: Received: 7 July 2020 / Approved: 9 July 2020 / Online: 9 July 2020 (12:58:28 CEST)
How to cite:
Portnova, G.; Girzhova, I.; Filatova, D.; Podlepich, V.; Tetereva, A.; Martynova, O. Brain Oscillatory Activity during Tactile Stimulation Correlates with Cortical Thickness of Intact Areas and Predicts Outcome in Comatose Patients. Preprints2020, 2020070196. https://doi.org/10.20944/preprints202007.0196.v1
Portnova, G.; Girzhova, I.; Filatova, D.; Podlepich, V.; Tetereva, A.; Martynova, O. Brain Oscillatory Activity during Tactile Stimulation Correlates with Cortical Thickness of Intact Areas and Predicts Outcome in Comatose Patients. Preprints 2020, 2020070196. https://doi.org/10.20944/preprints202007.0196.v1
Portnova, G.; Girzhova, I.; Filatova, D.; Podlepich, V.; Tetereva, A.; Martynova, O. Brain Oscillatory Activity during Tactile Stimulation Correlates with Cortical Thickness of Intact Areas and Predicts Outcome in Comatose Patients. Preprints2020, 2020070196. https://doi.org/10.20944/preprints202007.0196.v1
APA Style
Portnova, G., Girzhova, I., Filatova, D., Podlepich, V., Tetereva, A., & Martynova, O. (2020). Brain Oscillatory Activity during Tactile Stimulation Correlates with Cortical Thickness of Intact Areas and Predicts Outcome in Comatose Patients. Preprints. https://doi.org/10.20944/preprints202007.0196.v1
Chicago/Turabian Style
Portnova, G., Alina Tetereva and Olga Martynova. 2020 "Brain Oscillatory Activity during Tactile Stimulation Correlates with Cortical Thickness of Intact Areas and Predicts Outcome in Comatose Patients" Preprints. https://doi.org/10.20944/preprints202007.0196.v1
Abstract
This study reports a correlation between EEG and structural brain changes in patients after severe traumatic brain injury in a coma. The novelty of our approach was based on the combination of structural visualization (MRI) and functional neuroimaging (EEG) during tactile stimulation. The structural morphometry indicated a decrease of whole-brain cortical thickness, the gray-matter volume of the cortex, and subcortical structures in comatose patients compared to healthy subjects. In resting-state EEG, coma patients had significantly higher power of the slow-wave activity of 2-6 Hz and significantly less power of the alpha and beta rhythm. Importantly, coma patients showed a significant decrease of theta-rhythm power in tactile stimulation compared to the resting state, and this EEG pattern was not found in the control group. The decrease of the theta-rhythm power significantly correlated with the better outcome from a coma. Spectral changes in EEG in response to tactile stimuli showed no association with brain morphometric measures in healthy controls. In patients, decreasing theta-rhythm power correlated positively with the volume of whole-brain gray matter, right putamen, and insula; and negatively with the volume of damaged brain tissue. Increasing beta-rhythm power, specific tactile EEG response for a healthy brain, correlated with the cortical thickness of the somatosensory Paracentral and Precentral area. The observed decrease of gray-matter volume indicates brain atrophy in coma patients, which could be associated with neurodegeneration induced by injury. Our results also demonstrate that slow-wave desynchronization, as a nonspecific response to tactile stimulation, can serve as a sensitive index of morphometric changes after brain injury and coma outcome.
Keywords
coma; unconsiousness; EEG; MRI; Freesurfer; TBI
Subject
Medicine and Pharmacology, Neuroscience and Neurology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
