Preprint Review Version 1 This version is not peer-reviewed

Association of Maternal Iodine Intake with Congenital Hypothyroidism

Version 1 : Received: 27 June 2020 / Approved: 28 June 2020 / Online: 28 June 2020 (19:51:04 CEST)

How to cite: Gopika, P.; Sreelakshmi, M.; Nalwaya, S.; Bhyan, S.J. Association of Maternal Iodine Intake with Congenital Hypothyroidism. Preprints 2020, 2020060345 (doi: 10.20944/preprints202006.0345.v1). Gopika, P.; Sreelakshmi, M.; Nalwaya, S.; Bhyan, S.J. Association of Maternal Iodine Intake with Congenital Hypothyroidism. Preprints 2020, 2020060345 (doi: 10.20944/preprints202006.0345.v1).

Abstract

The iodine intake in a pregnant woman has been closely correlated with development of transient congenital hypothyroidism which leads to decline in neurocognitive abilities of the child later in life as the effects are very subtle at birth. Both low and excess ingestion of iodine has been found to contribute to this cause, although iodine deficiency is more commonly observed in women of underdeveloped nations. It poses risks not only to the foetus but also to the mother leading to obstetric complications such as still birth and spontaneous abortions. It can be prevented using WHO recommended daily iodine supplementation in deficient regions or decreasing the excess load in groups exposed to high iodine. Programmes designed to screen the new-born at birth can also help in improving the quality of life of the child. The deficient iodine condition is managed by administration of levothyroxine in dosage range of 10-15 mcg/kg/day. Generally, the prognosis of infants starting treatment early in life have a better neurocognitive outcome as compared to the treated infants late age at a later age. Avoidance of agents causing iodine exposure has resulted in decrease in the abnormal thyroid function levels.

Subject Areas

congenital hypothyroidism; transient; iodine deficiency; iodine excess; pregnancy; supplementation

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