PreprintArticleVersion 1Preserved in Portico This version is not peer-reviewed
Inflammatory Indicator and Hematological Indices in Contrast Induced Nephropathy among Patients Receiving Coronary Intervention: A Systematic Review and Meta-Analysis
Version 1
: Received: 14 June 2020 / Approved: 16 June 2020 / Online: 16 June 2020 (07:51:20 CEST)
How to cite:
Wu, X.; Ma, C.; Sun, D.; Zhang, G.; Wang, J.; Zhang, E. Inflammatory Indicator and Hematological Indices in Contrast Induced Nephropathy among Patients Receiving Coronary Intervention: A Systematic Review and Meta-Analysis. Preprints2020, 2020060199. https://doi.org/10.20944/preprints202006.0199.v1
Wu, X.; Ma, C.; Sun, D.; Zhang, G.; Wang, J.; Zhang, E. Inflammatory Indicator and Hematological Indices in Contrast Induced Nephropathy among Patients Receiving Coronary Intervention: A Systematic Review and Meta-Analysis. Preprints 2020, 2020060199. https://doi.org/10.20944/preprints202006.0199.v1
Wu, X.; Ma, C.; Sun, D.; Zhang, G.; Wang, J.; Zhang, E. Inflammatory Indicator and Hematological Indices in Contrast Induced Nephropathy among Patients Receiving Coronary Intervention: A Systematic Review and Meta-Analysis. Preprints2020, 2020060199. https://doi.org/10.20944/preprints202006.0199.v1
APA Style
Wu, X., Ma, C., Sun, D., Zhang, G., Wang, J., & Zhang, E. (2020). Inflammatory Indicator and Hematological Indices in Contrast Induced Nephropathy among Patients Receiving Coronary Intervention: A Systematic Review and Meta-Analysis. Preprints. https://doi.org/10.20944/preprints202006.0199.v1
Chicago/Turabian Style
Wu, X., Jinmiao Wang and Enyuan Zhang. 2020 "Inflammatory Indicator and Hematological Indices in Contrast Induced Nephropathy among Patients Receiving Coronary Intervention: A Systematic Review and Meta-Analysis" Preprints. https://doi.org/10.20944/preprints202006.0199.v1
Abstract
Background: Strong indicators of inflammation, such as C-reactive protein (CRP), hypersensitive CRP (hs-CRP), and a series of hematological indices, including platelet to lymphocyte ratio (PLR), neutrophil to lymphocyte ratio (NLR), hematocrit (HCT) and red blood cell distribution width (RDW), are regarded related with the incidence of contrast induced nephropathy (CIN) closely. Whereas, it remains unclear whether they can function as predictors of CIN onset. The objective of this meta-analysis was to determine the relationship between above indicators and CIN incidence among patients receiving coronary intervention. Methods: Clinical studies were retrieved from the electronic databases of PubMed, EMBASE, Google Scholar, Clinical Trials, and science direct from their inception to June 3rd, 2020. Meta-analysis was performed on pool eligible studies. Two reviewers screened all titles and abstracts and independently assessed all articles. Results: A total of 26 studies involving 29,454 patients were included in the meta-analysis. Pooled analysis results revealed that patients with higher CRP (odds ratio [OR]=1.06, 95% confidence interval [CI]: 1.01–1.12, P=0.02), hs-CRP (OR=1.03, 95% CI: 1.01–1.06, P=0.004), NLR (OR=1.11, 95% CI: 1.01–1.20, P=0.02), RDW (OR=1.35, 95% CI: 1.19–1.53, P<0.00001), and lower HCT (OR=0.94, 95% CI: 0.92–0.97, P=0.0003) all exhibited significantly higher CIN rates, but there was no significant association between PLR and CIN risk (OR=1.12, 95% CI: 0.99–1.26, P=0.07). Conclusion: The meta-analysis reported here demonstrates that pre-angiography CRP/hs-CRP and some hematological indices are associated with CIN.
Keywords
C-reactive protein; platelet to lymphocyte ratio; neutrophil to lymphocyte ratio; hematocrit; red blood cell distribution width; contrast induced nephropathy; coronary intervention
Subject
Medicine and Pharmacology, Cardiac and Cardiovascular Systems
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
