Version 1
: Received: 5 June 2020 / Approved: 7 June 2020 / Online: 7 June 2020 (11:57:52 CEST)
Version 2
: Received: 12 June 2020 / Approved: 14 June 2020 / Online: 14 June 2020 (16:49:10 CEST)
Ankur Das, Raja Ahmed, Suraiya Akhtar, Khaleda Begum, Sofia Banu,
An overview of basic molecular biology of SARS-CoV-2 and current COVID-19 prevention strategies,
Gene Reports,
Volume 23,
2021,
101122,
ISSN 2452-0144,
https://doi.org/10.1016/j.genrep.2021.101122.
(https://www.sciencedirect.com/science/article/pii/S2452014421001072)
Abstract: Coronavirus Disease 2019 (COVID-19) manifests as extreme acute respiratory conditions caused by a novel beta coronavirus named severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) which is reported to be the seventh coronavirus to infect humans. Like other SARS-CoVs it has a large positive-stranded RNA genome. But, specific furin site in the spike protein, mutation prone and phylogenetically mess open reading frame1ab (Orf1ab) separates SARS-CoV-2 from other RNA viruses. Since the outbreak (February–March 2020), researchers, scientists, and medical professionals are inspecting all possible facts and aspects including its replication, detection, and prevention strategies. This led to the prompt identification of its basic biology, genome characterization, structural and expression based functional information of proteins, and utilization of this information in optimizing strategies to prevent its spread. This review summarizes the recent updates on the basic molecular biology of SARS-CoV-2 and prevention strategies undertaken worldwide to tackle COVID-19. This recent information can be implemented for the development and designing of therapeutics against SARS-CoV-2.
Keywords: SARS-CoV-2; Genome organization and expression; Prevention strategies
Ankur Das, Raja Ahmed, Suraiya Akhtar, Khaleda Begum, Sofia Banu,
An overview of basic molecular biology of SARS-CoV-2 and current COVID-19 prevention strategies,
Gene Reports,
Volume 23,
2021,
101122,
ISSN 2452-0144,
https://doi.org/10.1016/j.genrep.2021.101122.
(https://www.sciencedirect.com/science/article/pii/S2452014421001072)
Abstract: Coronavirus Disease 2019 (COVID-19) manifests as extreme acute respiratory conditions caused by a novel beta coronavirus named severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) which is reported to be the seventh coronavirus to infect humans. Like other SARS-CoVs it has a large positive-stranded RNA genome. But, specific furin site in the spike protein, mutation prone and phylogenetically mess open reading frame1ab (Orf1ab) separates SARS-CoV-2 from other RNA viruses. Since the outbreak (February–March 2020), researchers, scientists, and medical professionals are inspecting all possible facts and aspects including its replication, detection, and prevention strategies. This led to the prompt identification of its basic biology, genome characterization, structural and expression based functional information of proteins, and utilization of this information in optimizing strategies to prevent its spread. This review summarizes the recent updates on the basic molecular biology of SARS-CoV-2 and prevention strategies undertaken worldwide to tackle COVID-19. This recent information can be implemented for the development and designing of therapeutics against SARS-CoV-2.
Keywords: SARS-CoV-2; Genome organization and expression; Prevention strategies
Ankur Das, Raja Ahmed, Suraiya Akhtar, Khaleda Begum, Sofia Banu,
An overview of basic molecular biology of SARS-CoV-2 and current COVID-19 prevention strategies,
Gene Reports,
Volume 23,
2021,
101122,
ISSN 2452-0144,
https://doi.org/10.1016/j.genrep.2021.101122.
(https://www.sciencedirect.com/science/article/pii/S2452014421001072)
Abstract: Coronavirus Disease 2019 (COVID-19) manifests as extreme acute respiratory conditions caused by a novel beta coronavirus named severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) which is reported to be the seventh coronavirus to infect humans. Like other SARS-CoVs it has a large positive-stranded RNA genome. But, specific furin site in the spike protein, mutation prone and phylogenetically mess open reading frame1ab (Orf1ab) separates SARS-CoV-2 from other RNA viruses. Since the outbreak (February–March 2020), researchers, scientists, and medical professionals are inspecting all possible facts and aspects including its replication, detection, and prevention strategies. This led to the prompt identification of its basic biology, genome characterization, structural and expression based functional information of proteins, and utilization of this information in optimizing strategies to prevent its spread. This review summarizes the recent updates on the basic molecular biology of SARS-CoV-2 and prevention strategies undertaken worldwide to tackle COVID-19. This recent information can be implemented for the development and designing of therapeutics against SARS-CoV-2.
Keywords: SARS-CoV-2; Genome organization and expression; Prevention strategies
Ankur Das, Raja Ahmed, Suraiya Akhtar, Khaleda Begum, Sofia Banu,
An overview of basic molecular biology of SARS-CoV-2 and current COVID-19 prevention strategies,
Gene Reports,
Volume 23,
2021,
101122,
ISSN 2452-0144,
https://doi.org/10.1016/j.genrep.2021.101122.
(https://www.sciencedirect.com/science/article/pii/S2452014421001072)
Abstract: Coronavirus Disease 2019 (COVID-19) manifests as extreme acute respiratory conditions caused by a novel beta coronavirus named severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) which is reported to be the seventh coronavirus to infect humans. Like other SARS-CoVs it has a large positive-stranded RNA genome. But, specific furin site in the spike protein, mutation prone and phylogenetically mess open reading frame1ab (Orf1ab) separates SARS-CoV-2 from other RNA viruses. Since the outbreak (February–March 2020), researchers, scientists, and medical professionals are inspecting all possible facts and aspects including its replication, detection, and prevention strategies. This led to the prompt identification of its basic biology, genome characterization, structural and expression based functional information of proteins, and utilization of this information in optimizing strategies to prevent its spread. This review summarizes the recent updates on the basic molecular biology of SARS-CoV-2 and prevention strategies undertaken worldwide to tackle COVID-19. This recent information can be implemented for the development and designing of therapeutics against SARS-CoV-2.
Keywords: SARS-CoV-2; Genome organization and expression; Prevention strategies
Abstract
COVID-19 manifests regarding extreme acute respiratory conditions caused by a novel beta coronavirus (SARS-CoV-2) which is reported to be the seventh coronavirus to infect humans. Like other SARS-CoVs it has a large positive-stranded RNA genome. But specific furin site in the spike protein, mutation prone and phylogenetically mess Orf1ab separates SARS-CoV-2 from other RNA viruses. Since, the outbreak (February - March 2020) which originated in China, researchers, scientists, and medical professionals are inspecting all possible facts from every possible aspect including its replication, detection, and prevention strategies. This led to the prompt identification of its basic biology, genome characterization, structural based functional information of proteins, and strategies to prevent its spread. Due to the rapid mutation rate, the functional characterization of a few proteins is still lagging. This review summarizes the recent updates on the basic molecular biology of SARS-CoV-2 and prevention strategies undertaken worldwide to tackle COVID-19. This recent information can be implemented for the development and designing of therapeutics against SARS-CoV-2.
Subject Areas
SARS-CoV-2; Genome organisation and expression; Polyproteins; Prevention strategies
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Received:
14 June 2020
Commenter:
Ankur Das
Commenter's Conflict of Interests:
Author
Comment:
1. English language editing has been done 2. Few typing mistakes have been corrected 3. Figure 4 caption has been corrected 4. Figures formate line has been added 5. Table caption has been added
Ankur Das
Commenter: Ankur Das
Commenter's Conflict of Interests: Author
2. Few typing mistakes have been corrected
3. Figure 4 caption has been corrected
4. Figures formate line has been added
5. Table caption has been added