An Overview of Basic Molecular Biology of SARS-CoV-2 and Current COVID-19 Prevention Strategies

Ankur Das; Raja Ahmed; Suraiya Akhtar; Khaleda Begum; Sofia Banu

doi:10.20944/preprints202006.0086.v2

Preprint Review Version 2 Preserved in Portico This version is not peer-reviewed

Version 1 : Received: 5 June 2020 / Approved: 7 June 2020 / Online: 7 June 2020 (11:57:52 CEST)
Version 2 : Received: 12 June 2020 / Approved: 14 June 2020 / Online: 14 June 2020 (16:49:10 CEST)

COVID-19 manifests regarding extreme acute respiratory conditions caused by a novel beta coronavirus (SARS-CoV-2) which is reported to be the seventh coronavirus to infect humans. Like other SARS-CoVs it has a large positive-stranded RNA genome. But specific furin site in the spike protein, mutation prone and phylogenetically mess Orf1ab separates SARS-CoV-2 from other RNA viruses. Since, the outbreak (February - March 2020) which originated in China, researchers, scientists, and medical professionals are inspecting all possible facts from every possible aspect including its replication, detection, and prevention strategies. This led to the prompt identification of its basic biology, genome characterization, structural based functional information of proteins, and strategies to prevent its spread. Due to the rapid mutation rate, the functional characterization of a few proteins is still lagging. This review summarizes the recent updates on the basic molecular biology of SARS-CoV-2 and prevention strategies undertaken worldwide to tackle COVID-19. This recent information can be implemented for the development and designing of therapeutics against SARS-CoV-2.

SARS-CoV-2; Genome organisation and expression; Polyproteins; Prevention strategies

Comment 1

Received: 14 June 2020
Commenter: Ankur Das
Commenter's Conflict of Interests: Author

Comment: 1. English language editing has been done
2. Few typing mistakes have been corrected
3. Figure 4 caption has been corrected
4. Figures formate line has been added
5. Table caption has been added

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An Overview of Basic Molecular Biology of SARS-CoV-2 and Current COVID-19 Prevention Strategies

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