Preprint Review Version 2 Preserved in Portico This version is not peer-reviewed

An Overview of Basic Molecular Biology of SARS-CoV-2 and Current COVID-19 Prevention Strategies

Version 1 : Received: 5 June 2020 / Approved: 7 June 2020 / Online: 7 June 2020 (11:57:52 CEST)
Version 2 : Received: 12 June 2020 / Approved: 14 June 2020 / Online: 14 June 2020 (16:49:10 CEST)

A peer-reviewed article of this Preprint also exists.

Ankur Das, Raja Ahmed, Suraiya Akhtar, Khaleda Begum, Sofia Banu, An overview of basic molecular biology of SARS-CoV-2 and current COVID-19 prevention strategies, Gene Reports, Volume 23, 2021, 101122, ISSN 2452-0144, https://doi.org/10.1016/j.genrep.2021.101122. (https://www.sciencedirect.com/science/article/pii/S2452014421001072) Abstract: Coronavirus Disease 2019 (COVID-19) manifests as extreme acute respiratory conditions caused by a novel beta coronavirus named severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) which is reported to be the seventh coronavirus to infect humans. Like other SARS-CoVs it has a large positive-stranded RNA genome. But, specific furin site in the spike protein, mutation prone and phylogenetically mess open reading frame1ab (Orf1ab) separates SARS-CoV-2 from other RNA viruses. Since the outbreak (February–March 2020), researchers, scientists, and medical professionals are inspecting all possible facts and aspects including its replication, detection, and prevention strategies. This led to the prompt identification of its basic biology, genome characterization, structural and expression based functional information of proteins, and utilization of this information in optimizing strategies to prevent its spread. This review summarizes the recent updates on the basic molecular biology of SARS-CoV-2 and prevention strategies undertaken worldwide to tackle COVID-19. This recent information can be implemented for the development and designing of therapeutics against SARS-CoV-2. Keywords: SARS-CoV-2; Genome organization and expression; Prevention strategies Ankur Das, Raja Ahmed, Suraiya Akhtar, Khaleda Begum, Sofia Banu, An overview of basic molecular biology of SARS-CoV-2 and current COVID-19 prevention strategies, Gene Reports, Volume 23, 2021, 101122, ISSN 2452-0144, https://doi.org/10.1016/j.genrep.2021.101122. (https://www.sciencedirect.com/science/article/pii/S2452014421001072) Abstract: Coronavirus Disease 2019 (COVID-19) manifests as extreme acute respiratory conditions caused by a novel beta coronavirus named severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) which is reported to be the seventh coronavirus to infect humans. Like other SARS-CoVs it has a large positive-stranded RNA genome. But, specific furin site in the spike protein, mutation prone and phylogenetically mess open reading frame1ab (Orf1ab) separates SARS-CoV-2 from other RNA viruses. Since the outbreak (February–March 2020), researchers, scientists, and medical professionals are inspecting all possible facts and aspects including its replication, detection, and prevention strategies. This led to the prompt identification of its basic biology, genome characterization, structural and expression based functional information of proteins, and utilization of this information in optimizing strategies to prevent its spread. This review summarizes the recent updates on the basic molecular biology of SARS-CoV-2 and prevention strategies undertaken worldwide to tackle COVID-19. This recent information can be implemented for the development and designing of therapeutics against SARS-CoV-2. Keywords: SARS-CoV-2; Genome organization and expression; Prevention strategies

Journal reference: Gene Reports 2021, 23, 101122
DOI: 10.1016/j.genrep.2021.101122

Abstract

COVID-19 manifests regarding extreme acute respiratory conditions caused by a novel beta coronavirus (SARS-CoV-2) which is reported to be the seventh coronavirus to infect humans. Like other SARS-CoVs it has a large positive-stranded RNA genome. But specific furin site in the spike protein, mutation prone and phylogenetically mess Orf1ab separates SARS-CoV-2 from other RNA viruses. Since, the outbreak (February - March 2020) which originated in China, researchers, scientists, and medical professionals are inspecting all possible facts from every possible aspect including its replication, detection, and prevention strategies. This led to the prompt identification of its basic biology, genome characterization, structural based functional information of proteins, and strategies to prevent its spread. Due to the rapid mutation rate, the functional characterization of a few proteins is still lagging. This review summarizes the recent updates on the basic molecular biology of SARS-CoV-2 and prevention strategies undertaken worldwide to tackle COVID-19. This recent information can be implemented for the development and designing of therapeutics against SARS-CoV-2.

Subject Areas

SARS-CoV-2; Genome organisation and expression; Polyproteins; Prevention strategies

Comments (1)

Comment 1
Received: 14 June 2020
Commenter: Ankur Das
Commenter's Conflict of Interests: Author
Comment: 1. English language editing has been done
2. Few typing mistakes have been corrected
3. Figure 4 caption has been corrected
4. Figures formate line has been added
5. Table caption has been added
 
+ Respond to this comment

We encourage comments and feedback from a broad range of readers. See criteria for comments and our diversity statement.

Leave a public comment
Send a private comment to the author(s)
Views 0
Downloads 0
Comments 1
Metrics 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.