Version 1
: Received: 5 June 2020 / Approved: 7 June 2020 / Online: 7 June 2020 (11:57:52 CEST)
Version 2
: Received: 12 June 2020 / Approved: 14 June 2020 / Online: 14 June 2020 (16:49:10 CEST)
Das, A.; Ahmed, R.; Akhtar, S.; Begum, K.; Banu, S. An Overview of Basic Molecular Biology of SARS-CoV-2 and Current COVID-19 Prevention Strategies. Gene Reports, 2021, 23, 101122. https://doi.org/10.1016/j.genrep.2021.101122.
Das, A.; Ahmed, R.; Akhtar, S.; Begum, K.; Banu, S. An Overview of Basic Molecular Biology of SARS-CoV-2 and Current COVID-19 Prevention Strategies. Gene Reports, 2021, 23, 101122. https://doi.org/10.1016/j.genrep.2021.101122.
Das, A.; Ahmed, R.; Akhtar, S.; Begum, K.; Banu, S. An Overview of Basic Molecular Biology of SARS-CoV-2 and Current COVID-19 Prevention Strategies. Gene Reports, 2021, 23, 101122. https://doi.org/10.1016/j.genrep.2021.101122.
Das, A.; Ahmed, R.; Akhtar, S.; Begum, K.; Banu, S. An Overview of Basic Molecular Biology of SARS-CoV-2 and Current COVID-19 Prevention Strategies. Gene Reports, 2021, 23, 101122. https://doi.org/10.1016/j.genrep.2021.101122.
Abstract
COVID-19 manifests regarding extreme acute respiratory conditions caused by a novel beta coronavirus (SARS-CoV-2) which is reported to be the seventh coronavirus to infect humans. Like other SARS-CoVs it has a large positive-stranded RNA genome. But specific furin site in the spike protein, mutation prone and phylogenetically mess Orf1ab separates SARS-CoV-2 from other RNA viruses. Since, the outbreak (February - March 2020) which originated in China, researchers, scientists, and medical professionals are inspecting all possible facts from every possible aspects including its replication, detection and prevention strategies. This led to the prompt identification of its basic biology, genome characterization, structural based functional information of proteins and strategies to prevent its spread. Due to rapid mutation rate, functional characterization of few proteins is still lagging. This review summarizes the recent updates on basic molecular biology of SARS-CoV-2 and prevention strategies undertaken worldwide to tackle COVID-19. This recent information can be implemented for the development and designing of therapeutics against SARS-CoV-2.
Keywords
SARS-CoV-2; Genome organisation and expression; Polyproteins; Prevention strategies
Subject
Biology and Life Sciences, Virology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
