SARS-CoV2 Envelope Protein: Non-Synonymous Mutations and Its Consequences

Sk Sarif Hassan; Pabitra Pal Choudhury; Bidyut Roy

doi:10.20944/preprints202006.0072.v1

Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Version 1 : Received: 7 June 2020 / Approved: 7 June 2020 / Online: 7 June 2020 (09:20:25 CEST)

In the NCBI database, as on June 6, 2020, total number of available complete genome sequences of SARS-CoV2 across the world is 3617. The envelope protein of SARS-CoV2 possesses several non-synonymous mutations over the transmembrane domain and (C)-terminus in 0.414\% of these 3617 genomes. The C-terminus motif DLLV has been changed to DFLV and YLLV in the proteins QJR88103 (Australia: Victoria) and QKI36831 (China: Guangzhou) respectively, which might affect the binding of this motif with the host protein PALS1.

Envelope protein; SARS-CoV2; COVID-19; Non-synonymous mutations

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SARS-CoV2 Envelope Protein: Non-Synonymous Mutations and Its Consequences

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