Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

SARS-CoV2 Envelope Protein: Non-Synonymous Mutations and Its Consequences

Version 1 : Received: 7 June 2020 / Approved: 7 June 2020 / Online: 7 June 2020 (09:20:25 CEST)

How to cite: Hassan, S.S.; Pal Choudhury, P.; Roy, B. SARS-CoV2 Envelope Protein: Non-Synonymous Mutations and Its Consequences. Preprints 2020, 2020060072 (doi: 10.20944/preprints202006.0072.v1). Hassan, S.S.; Pal Choudhury, P.; Roy, B. SARS-CoV2 Envelope Protein: Non-Synonymous Mutations and Its Consequences. Preprints 2020, 2020060072 (doi: 10.20944/preprints202006.0072.v1).

Abstract

In the NCBI database, as on June 6, 2020, total number of available complete genome sequences of SARS-CoV2 across the world is 3617. The envelope protein of SARS-CoV2 possesses several non-synonymous mutations over the transmembrane domain and (C)-terminus in 0.414\% of these 3617 genomes. The C-terminus motif DLLV has been changed to DFLV and YLLV in the proteins QJR88103 (Australia: Victoria) and QKI36831 (China: Guangzhou) respectively, which might affect the binding of this motif with the host protein PALS1.

Subject Areas

Envelope protein; SARS-CoV2; COVID-19; Non-synonymous mutations

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