Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

SARS-CoV2 Envelope Protein: Non-Synonymous Mutations and Its Consequences

Version 1 : Received: 7 June 2020 / Approved: 7 June 2020 / Online: 7 June 2020 (09:20:25 CEST)

How to cite: Hassan, S.S.; Pal Choudhury, P.; Roy, B. SARS-CoV2 Envelope Protein: Non-Synonymous Mutations and Its Consequences. Preprints 2020, 2020060072. https://doi.org/10.20944/preprints202006.0072.v1 Hassan, S.S.; Pal Choudhury, P.; Roy, B. SARS-CoV2 Envelope Protein: Non-Synonymous Mutations and Its Consequences. Preprints 2020, 2020060072. https://doi.org/10.20944/preprints202006.0072.v1

Abstract

In the NCBI database, as on June 6, 2020, total number of available complete genome sequences of SARS-CoV2 across the world is 3617. The envelope protein of SARS-CoV2 possesses several non-synonymous mutations over the transmembrane domain and (C)-terminus in 0.414\% of these 3617 genomes. The C-terminus motif DLLV has been changed to DFLV and YLLV in the proteins QJR88103 (Australia: Victoria) and QKI36831 (China: Guangzhou) respectively, which might affect the binding of this motif with the host protein PALS1.

Keywords

Envelope protein; SARS-CoV2; COVID-19; Non-synonymous mutations

Subject

Biology and Life Sciences, Virology

Comments (0)

Comment 1
Received: 19 December 2021
Commenter: Wayne Miller
The commenter has declared there is no conflict of interests.
Comment: I am wondering if you can point to any very current publications that address the issue of nucleocapsid protein mutations in the latest SARS CoV II varients? Thank you.
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