An Atlas of the Genetic Variations Linking Dysregulation of Autophagy to Human Diseases: The Missing Environmental Link

How to cite: Grosjean, I.; Roméo, B.; Domdom, M.; Yazbeck, N.; D’Andréa, G.; Belaid, A.; Camuzard, O.; Vidal, O.; Crépeaux, G.; Gherardi, R.K.; Authier, F.J.; Masson, J.D.; Gilson, E.; Marquette, C.H.; Leroy, S.; Roux, J.; Brest, P.; Von Bergen, M.; Milano, G.; Klionsky, D.J.; Hofman, P.; Mograbi, B. An Atlas of the Genetic Variations Linking Dysregulation of Autophagy to Human Diseases: The Missing Environmental Link. Preprints 2020, 2020060026 Grosjean, I.; Roméo, B.; Domdom, M.; Yazbeck, N.; D’Andréa, G.; Belaid, A.; Camuzard, O.; Vidal, O.; Crépeaux, G.; Gherardi, R.K.; Authier, F.J.; Masson, J.D.; Gilson, E.; Marquette, C.H.; Leroy, S.; Roux, J.; Brest, P.; Von Bergen, M.; Milano, G.; Klionsky, D.J.; Hofman, P.; Mograbi, B. An Atlas of the Genetic Variations Linking Dysregulation of Autophagy to Human Diseases: The Missing Environmental Link. Preprints 2020, 2020060026

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MDPI and ACS Style

Grosjean, I.; Roméo, B.; Domdom, M.; Yazbeck, N.; D’Andréa, G.; Belaid, A.; Camuzard, O.; Vidal, O.; Crépeaux, G.; Gherardi, R.K.; Authier, F.J.; Masson, J.D.; Gilson, E.; Marquette, C.H.; Leroy, S.; Roux, J.; Brest, P.; Von Bergen, M.; Milano, G.; Klionsky, D.J.; Hofman, P.; Mograbi, B. An Atlas of the Genetic Variations Linking Dysregulation of Autophagy to Human Diseases: The Missing Environmental Link. Preprints 2020, 2020060026

APA Style

Grosjean, I., Roméo, B., Domdom, M., Yazbeck, N., D’Andréa, G., Belaid, A., Camuzard, O., Vidal, O., Crépeaux, G., Gherardi, R.K., Authier, F.J., Masson, J.D., Gilson, E., Marquette, C.H., Leroy, S., Roux, J., Brest, P., Von Bergen, M., Milano, G., Klionsky, D.J., Hofman, P., & Mograbi, B. (2020). An Atlas of the Genetic Variations Linking Dysregulation of Autophagy to Human Diseases: The Missing Environmental Link. Preprints. https://doi.org/

Chicago/Turabian Style

Grosjean, I., Paul Hofman and Baharia Mograbi. 2020 "An Atlas of the Genetic Variations Linking Dysregulation of Autophagy to Human Diseases: The Missing Environmental Link" Preprints. https://doi.org/

Abstract

The rising incidence of complex illnesses and their costs have revolutionized basic research, patient management, and societal needs. Between 70 to 90% of the risk of developing a disease is due to the air we breathe, the water we drink, and the surroundings in which we work and live. Visibly polluted, infectious or not, the fact remains that we are more than ever exposed to environmental risks. Air pollution is the fourth most prevalent deadly risk factor worldwide and by far the leading risk factor for hundreds of diseases, including respiratory infections, inflammatory illness, and cancer. Thus, an unhealthy environment can be considered as a pandemic, affecting 280 million people and claiming 12 million deaths every year. Although critical for identifying of the people at risk, the causal environment components (pollutants and/or the microbiome), and the affected physiological mechanisms are not well understood. Herein, we consider the dysregulation of macroautophagy (hereafter referred to as ‘autophagy’), as the mechanism at the heart of an immediate response to environmental stress. We discuss the missing link between the autophagy gene variations, and the exposome in the susceptibility, prognosis, and management of complex diseases when embracing personalized medicine.

Keywords

air pollutants/exposomics; autoimmunity; autophagy; cancers; COPD; environmental diseases; eQTL; infection; inflammatory; polymorphism; prognosis; risk; susceptibility; theragnosis

Subject

Medicine and Pharmacology, Oncology and Oncogenics

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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