Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Timing of Complementary Feeding in Preterm Infants is not Associated with Early Adiposity Rebound: Longitudinal Analysis of BMI Data from Birth to 7 Years

Version 1 : Received: 1 June 2020 / Approved: 4 June 2020 / Online: 4 June 2020 (03:24:10 CEST)

How to cite: Baldassarre, M.E.; Di Mauro, A.; Caroli, M.; Schettini, F.; Rizzo, V.; De Giorgi, A.; Fanelli, M.; Laforgia, N. Timing of Complementary Feeding in Preterm Infants is not Associated with Early Adiposity Rebound: Longitudinal Analysis of BMI Data from Birth to 7 Years. Preprints 2020, 2020060020 (doi: 10.20944/preprints202006.0020.v1). Baldassarre, M.E.; Di Mauro, A.; Caroli, M.; Schettini, F.; Rizzo, V.; De Giorgi, A.; Fanelli, M.; Laforgia, N. Timing of Complementary Feeding in Preterm Infants is not Associated with Early Adiposity Rebound: Longitudinal Analysis of BMI Data from Birth to 7 Years. Preprints 2020, 2020060020 (doi: 10.20944/preprints202006.0020.v1).

Abstract

Background: Adiposity rebound (AR) refers to the second rise of the BMI curve that usually occurs physiologically between 5 and 7 years of age. AR timing has a great impact on children´s health, being the early adiposity rebound (EAR) associated with the development of metabolic disease later in life. Aim: We aimed to investigate the prevalence of EAR in a cohort of preterm newborns. Secondary outcomes evaluated if some determinants such as (1) gender (male/female), (2) type of delivery (caesarean/vaginal), (3) birth weight (SGA/NGA/LGA), (4) type of feeding (5) duration of breastfeeding, (6) timing of introduction of solid food, (7) parental education and (8) parental pre-pregnancy BMI can influence EAR in this cohort. Tertiary aim was to evaluate the prevalence of obesity or overweight at 7 years of age in children according to early versus timely AR. Methods: This is a perspective, population-based longitudinal study, where infants born preterm were evaluated at birth and at 1, 3, 6, 9, 12, 15, 18, 24 months and 3, 4, 5, 6, 7 years of gestational-corrected age. Weight and height data were analyzed, and BMI was calculated. AR was assessed in the growth trajectory in a body mass index (BMI) plot. Results: Of the 250 preterm newborns included, 100 completed the 7 years follow-up and entered in the final analysis. The prevalence of EAR in our cohort of preterm newborns was 54%. EAR was associated with being LGA at birth. No other factors were associated to EAR. Early adiposity rebounders have a significant higher BMI at 7 years compared to children with timely AR (17.2 ±2.7 vs 15.6 ± 2.05, p=0.021). No significant differences were found in the prevalence of obesity or overweight at 7 years of age in children with early or timely AR (29% vs 14% p=0.202). Conclusions: Clinical management of preterm infants should focus on reducing excess weight gain to prevent long-term metabolic risk. Others neonatal factors are not associated to an higher risk of EAR.

Subject Areas

Adiposity rebound; Infant; Premature; Pediatric Obesity; Complementary Feeding; Weaning; Body Mass Index

Comments (2)

Comment 1
Received: 9 June 2020
Commenter: Devi Dayal (Click to see Publons profile: )
The commenter has declared there is no conflict of interests.
Comment: It may be useful for authors to have a look at our article on similar topic: Longitudinal observations on growth patterns of obese infants: Developing country perspectives. Preliminary study Pediatria polska 2017. DOI: 10.1016/j.pepo.2017.04.002
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Response 1 to Comment 1
Received: 9 June 2020
Commenter: Maria Elisabetta Baldassarre
The commenter has declared there is no conflict of interests.
Comment: I will have a look to your article, thank you for your interest in our work

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