Version 1
: Received: 14 May 2020 / Approved: 16 May 2020 / Online: 16 May 2020 (04:19:07 CEST)
How to cite:
Thomson, T.M.; Toscano, E.; Casis, E.; Paciucci, R. C1-INH and the Contact System in COVID-19-Associated Coagulopathy. Preprints2020, 2020050262. https://doi.org/10.20944/preprints202005.0262.v1
Thomson, T.M.; Toscano, E.; Casis, E.; Paciucci, R. C1-INH and the Contact System in COVID-19-Associated Coagulopathy. Preprints 2020, 2020050262. https://doi.org/10.20944/preprints202005.0262.v1
Thomson, T.M.; Toscano, E.; Casis, E.; Paciucci, R. C1-INH and the Contact System in COVID-19-Associated Coagulopathy. Preprints2020, 2020050262. https://doi.org/10.20944/preprints202005.0262.v1
APA Style
Thomson, T.M., Toscano, E., Casis, E., & Paciucci, R. (2020). C1-INH and the Contact System in COVID-19-Associated Coagulopathy. Preprints. https://doi.org/10.20944/preprints202005.0262.v1
Chicago/Turabian Style
Thomson, T.M., Ernesto Casis and Rosanna Paciucci. 2020 "C1-INH and the Contact System in COVID-19-Associated Coagulopathy" Preprints. https://doi.org/10.20944/preprints202005.0262.v1
Abstract
COVID-19 is frequently associated with a coagulopathy with severe consequences. The mechanisms leading to a pro-coagulant state in these patients is multifactorial, including tissue destruction and inflammatory mechanisms. Based on the analysis of publicly available interactomes, we propose that SARS-CoV-2 infection causes a deficiency in C1 esterase inhibitor (C1-INH), a pathogen-specific mechanism that may help explain the pro-coagulant state in COVID-19 patients.
Keywords
COVID-19; coagulopathy; C1-INH
Subject
Medicine and Pharmacology, Pathology and Pathobiology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
