Preprint Hypothesis Version 1 Preserved in Portico This version is not peer-reviewed

C1-INH and the Contact System in COVID-19-Associated Coagulopathy

Version 1 : Received: 14 May 2020 / Approved: 16 May 2020 / Online: 16 May 2020 (04:19:07 CEST)

How to cite: Thomson, T.M.; Toscano, E.; Casis, E.; Paciucci, R. C1-INH and the Contact System in COVID-19-Associated Coagulopathy. Preprints 2020, 2020050262 (doi: 10.20944/preprints202005.0262.v1). Thomson, T.M.; Toscano, E.; Casis, E.; Paciucci, R. C1-INH and the Contact System in COVID-19-Associated Coagulopathy. Preprints 2020, 2020050262 (doi: 10.20944/preprints202005.0262.v1).

Abstract

COVID-19 is frequently associated with a coagulopathy with severe consequences. The mechanisms leading to a pro-coagulant state in these patients is multifactorial, including tissue destruction and inflammatory mechanisms. Based on the analysis of publicly available interactomes, we propose that SARS-CoV-2 infection causes a deficiency in C1 esterase inhibitor (C1-INH), a pathogen-specific mechanism that may help explain the pro-coagulant state in COVID-19 patients.

Subject Areas

COVID-19; coagulopathy; C1-INH

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