C1-INH and the Contact System in COVID-19-Associated Coagulopathy

Timothy M. Thomson; Emily Toscano; Ernesto Casis; Rosanna Paciucci

doi:10.20944/preprints202005.0262.v1

Submitted:

14 May 2020

Posted:

16 May 2020

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Preprints on COVID-19 and SARS-CoV-2

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Hypothesis

This version is not peer-reviewed.

C1-INH and the Contact System in COVID-19-Associated Coagulopathy

Timothy M. Thomson^*,Emily Toscano,Ernesto Casis,Rosanna Paciucci

Submitted:

14 May 2020

Posted:

16 May 2020

You are already at the latest version

Part of the Following Collection

Preprints on COVID-19 and SARS-CoV-2

Abstract

COVID-19 is frequently associated with a coagulopathy with severe consequences. The mechanisms leading to a pro-coagulant state in these patients is multifactorial, including tissue destruction and inflammatory mechanisms. Based on the analysis of publicly available interactomes, we propose that SARS-CoV-2 infection causes a deficiency in C1 esterase inhibitor (C1-INH), a pathogen-specific mechanism that may help explain the pro-coagulant state in COVID-19 patients.

Keywords:

COVID-19

;

coagulopathy

;

C1-INH

Subject:

Medicine and Pharmacology - Pathology and Pathobiology

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