Version 1
: Received: 12 May 2020 / Approved: 14 May 2020 / Online: 14 May 2020 (11:54:31 CEST)
Version 2
: Received: 17 May 2020 / Approved: 17 May 2020 / Online: 17 May 2020 (15:27:24 CEST)
How to cite:
Tang, H.; Ali, M.; Zhang, L.; Deng, C. Raising Concern About Cross-Infection Between Humans and Companion Animals by Evolutionary Analysis of Receptors for SARS-CoV-2. Preprints2020, 2020050238
Tang, H.; Ali, M.; Zhang, L.; Deng, C. Raising Concern About Cross-Infection Between Humans and Companion Animals by Evolutionary Analysis of Receptors for SARS-CoV-2. Preprints 2020, 2020050238
Tang, H.; Ali, M.; Zhang, L.; Deng, C. Raising Concern About Cross-Infection Between Humans and Companion Animals by Evolutionary Analysis of Receptors for SARS-CoV-2. Preprints2020, 2020050238
APA Style
Tang, H., Ali, M., Zhang, L., & Deng, C. (2020). Raising Concern About Cross-Infection Between Humans and Companion Animals by Evolutionary Analysis of Receptors for SARS-CoV-2. Preprints. https://doi.org/
Chicago/Turabian Style
Tang, H., Lina Zhang and Cheng Deng. 2020 "Raising Concern About Cross-Infection Between Humans and Companion Animals by Evolutionary Analysis of Receptors for SARS-CoV-2" Preprints. https://doi.org/
Abstract
Since the COVID-19 caused by SARS-CoV-2 break out in Wuhan China from Dec. 2019, it has spread to hundreds of countries up to now. Scientists from all over the world have paid tremendous efforts to research and try to control the disease. Previous studies suggested that some of the wild animals could be intermediate hosts between humans and origination of SARS-CoV-2, and some companion animals of humans can be infected by SARS-CoV-2, which raised our curiosity about cross-infection of SARS-CoV-2 between animals and humans. Thus, we select some kinds of animals that might have contact with humans to estimate the susceptibility to SARS-CoV-2 in different animals by evolutionary analysis of their receptors for SARS-CoV-2. The results show that some companion animals of the Felidae family like the cat has a higher infection possibility while the species of the Rodent family like the rat and mouse having close contact with humans show an opposite result, which consist with recent animal experiments and researches. These should raise concerns about cross-infection between human and companion animals or animals to have close contact with humans which might grow into depositaries of the virus after control of SARS-CoV-2 spreading and cause second or more infection wave after social reopening. Another side of our results stands by the opinion that bioinformatic analysis can be consistent with practical experiments in some respects so that we can prevent unnecessary sacrifice of laboratory animals in future experiments.
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
