Preprint Brief Report Version 1 Preserved in Portico This version is not peer-reviewed

Saliva Glycoproteins Bind to Spike Protein of SARS-CoV-2

Version 1 : Received: 10 May 2020 / Approved: 11 May 2020 / Online: 11 May 2020 (10:24:43 CEST)

How to cite: Zhou, D.; Wu, C. Saliva Glycoproteins Bind to Spike Protein of SARS-CoV-2. Preprints 2020, 2020050192 (doi: 10.20944/preprints202005.0192.v1). Zhou, D.; Wu, C. Saliva Glycoproteins Bind to Spike Protein of SARS-CoV-2. Preprints 2020, 2020050192 (doi: 10.20944/preprints202005.0192.v1).

Abstract

We analyzed the affinity-proteomics data of saliva absorbed to plate-bound Spike protein of SARS-CoV-2, and identified major virus-binding proteins as MUC7, MUC5B, DMBT1, and neutrophil defensins. Furthermore, we found that saliva from healthy donors inhibited the binding of Spike-protein-specific polyclonal antibodies to Spike antigen. These data suggest that the Spike protein’s glycoprotein-binding domains (GBD) may be targeted to block virus adherence or entry of SARS-CoV-2.

Subject Areas

SARS-CoV2; corona virus; affinity proteomics; glycoproteins; glycoprotein-binding domains

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