Preprint Brief Report Version 1 Preserved in Portico This version is not peer-reviewed

Saliva Glycoproteins Bind to Spike Protein of SARS-CoV-2

Version 1 : Received: 10 May 2020 / Approved: 11 May 2020 / Online: 11 May 2020 (10:24:43 CEST)

How to cite: Zhou, D.; Wu, C. Saliva Glycoproteins Bind to Spike Protein of SARS-CoV-2. Preprints 2020, 2020050192. Zhou, D.; Wu, C. Saliva Glycoproteins Bind to Spike Protein of SARS-CoV-2. Preprints 2020, 2020050192.


We analyzed the affinity-proteomics data of saliva absorbed to plate-bound Spike protein of SARS-CoV-2, and identified major virus-binding proteins as MUC7, MUC5B, DMBT1, and neutrophil defensins. Furthermore, we found that saliva from healthy donors inhibited the binding of Spike-protein-specific polyclonal antibodies to Spike antigen. These data suggest that the Spike protein’s glycoprotein-binding domains (GBD) may be targeted to block virus adherence or entry of SARS-CoV-2.


SARS-CoV2; corona virus; affinity proteomics; glycoproteins; glycoprotein-binding domains


Medicine and Pharmacology, Medicine and Pharmacology

Comments (0)

Comment 1
Received: 16 May 2020
Commenter: Nima Farshidfar
The commenter has declared there is no conflict of interests.
Comment: Dear Drs. Dapeng Zhou and Chenghao Wu

I have read your interesting manuscript and hope it pave the way for future research. In addition, we have published an article entitled" Hyposalivation as a potential risk for SARS-CoV-2 infection: Inhibitory role of saliva " which i thought might be interesting to you as well. here is a summary of our recent article :
Considering the presence of many proteins with established antiviral properties in saliva, some of which can potentially inhibit virus replication especially coronavirus, it gives the impression that the protective effect of these salivary proteins against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) might be the same. Therefore, hyposalivation could be a potential risk factor for acute respiratory infection. It may expose patients at high risk of getting coronavirus disease (COVID-19).

Best Regards
Nima Farshidfar
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