Submitted:
10 May 2020
Posted:
11 May 2020
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Preprints on COVID-19 and SARS-CoV-2
Abstract
We analyzed the affinity-proteomics data of saliva absorbed to plate-bound Spike protein of SARS-CoV-2, and identified major virus-binding proteins as MUC7, MUC5B, DMBT1, and neutrophil defensins. Furthermore, we found that saliva from healthy donors inhibited the binding of Spike-protein-specific polyclonal antibodies to Spike antigen. These data suggest that the Spike protein’s glycoprotein-binding domains (GBD) may be targeted to block virus adherence or entry of SARS-CoV-2.
Keywords:
SARS-CoV2
; corona virus
; affinity proteomics
; glycoproteins
; glycoprotein-binding domains
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