Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

COVID-19 Clinical and Laboratory Diagnosis Overview

Version 1 : Received: 7 May 2020 / Approved: 8 May 2020 / Online: 8 May 2020 (12:26:46 CEST)

How to cite: Zayed, R.; Omran, D.; Zayed, A. COVID-19 Clinical and Laboratory Diagnosis Overview. Preprints 2020, 2020050142 (doi: 10.20944/preprints202005.0142.v1). Zayed, R.; Omran, D.; Zayed, A. COVID-19 Clinical and Laboratory Diagnosis Overview. Preprints 2020, 2020050142 (doi: 10.20944/preprints202005.0142.v1).

Abstract

COVID-19 was identified in Wuhan, China in in December 2019, and rapidly spread worldwide, being declared global pandemic one month later on 30 January 2020. Since its emergence, COVID-19 has raised global concerns associated with drastic measures that were never adopted in any previous outbreak, to contain the situation as early as possible. The 2019 novel corona virus (2019-nCoV) or SARS-CoV-2 is the causative agent of COVID-19. 2019-nCoV genetic sequence was rapidly identified within few days since the first reported cases and RT-PCR kits became available for COVID-19 diagnosis. However, RT-PCR diagnosis carries a risk of false-negative results, therefore additional serologic test are needed. The most important approach in the battle against COVID-19 is rapid diagnosis of suspicious cases, timely therapeutic intervention and isolation to avoid community spread. In this review, we summarize the clinical scenario that raises suspicion of COVID-19 and available laboratory diagnostics.

Subject Areas

COVID-19; serology; RT-PCR; lab; clinical

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