The Role of Temperature in COVID-19 Disease Severity and Transmission Rates

Dominique Kang; Clifford Ellgen

doi:10.20944/preprints202005.0070.v1

Comment 1

Received: 19 July 2020
Commenter: Erik Kulstad
Commenter's Conflict of Interests: Equity ownership of a company, Attune Medical, with technology in the patient temperature management space.

Comment: Excellent overview of a topic of increasing interest, highlighting the potential relevant factor of body temperature in case fatality rate of COVID-19, and showing that body temperature may be among the many factors associated with age and sex that may help explain the differences in COVID-19 case fatality rate. Drs. Anne Drewry and Richard Hotchkiss out of Washington University in St. Louis have done groundbreaking work in this area, including the first randomized-controlled clinical trial on External Warming in Septic Patients (ClinicalTrials.gov Identifier: NCT02706275). We've recently published a mathematical model of of patient warming, "The Use of Core Warming as a Treatment for Coronavirus Disease 2019 (COVID-19): an Initial Mathematical Model" (https://www.jca.org.br/jca/article/view/3382), and posted a planned clinical trial protocol, "Core warming of coronavirus disease 2019 (COVID-19) patients undergoing mechanical ventilation: protocol for a randomized controlled pilot study" (https://www.medrxiv.org/content/10.1101/2020.04.03.20052001v1). Further clinical study is beginning, which we look forward to sharing once available.

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The Role of Temperature in COVID-19 Disease Severity and Transmission Rates

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