Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Relative Handgrip Strength is Inversely Associated with the Presence of Type 2 Diabetes in Overweight Elderly Women with Varying Nutritional Status

Version 1 : Received: 21 April 2020 / Approved: 24 April 2020 / Online: 24 April 2020 (13:52:32 CEST)

A peer-reviewed article of this Preprint also exists.

Journal reference: Acta Diabetol 2021
DOI: 10.1007/s00592-020-01588-4


Background and Aims: We aimed to investigate cross-sectional relationships of relative handgrip strength (RHGS) with presence of diabetes and hypertension in a community setting. Methods and Results: Between 2016 and 2018, we enrolled 601 consecutive women with an average age of 70.7 ± 6.9 years (mean ± SD). Nutritional status was evaluated by the Mini Nutritional Assessment (MNA) score. Muscular strength and level of fitness were assessed by handgrip strength (HGS) and other standardized physical functional tests. The majority of participants were overweight or obese (80% with BMI > 25). Prevalence of diabetes and hypertension was 13 and 60%, respectively. Participants in the lowest quartile of HGS adjusted for BMI (RHGS) had significantly higher prevalence of diabetes and hypertension compared with those in the lower quartile (20.7 vs. 5.3% and 49.3 vs. 39.3%, respectively, p < 0.01 for both), whereas differences in nutritional status were not observed. Likelihood of having diabetes was significantly reduced in women with higher RHGS values (OR 0.77; 0.59–0.86 CI95%; p=0.002), independently of age, abdominal adiposity and presence of hypertension. RHGS was positively correlated with most of the physical functional tests performed. Conclusion: RHGS is an easy-to-obtain and inexpensive measure of muscular strength, independently associated with presence of diabetes in overweight elderly women. Prospective studies are required to assess its predictive value in individuals at risk of new onset or progression of diabetes.


nutrition status; muscle strength; diabetes; handgrip; insulin resistance; functional tests



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