Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Role of Vitamin D in Pathogenesis and Severity of COVID-19 Infection

Version 1 : Received: 19 April 2020 / Approved: 20 April 2020 / Online: 20 April 2020 (01:37:43 CEST)

A peer-reviewed article of this Preprint also exists.

Journal reference: The Journal of Metabolic Diseases 2020
DOI: 10.1080/13813455.2020.1792505


Coronavirus disease (COVID-19) is an infectious disease caused by a new virus which causes respiratory illness. Older adults and people who have previous chronic medical conditions are at higher risk for more serious complications from COVID-19.Hypovitaminosis D is attributed to the increased risk of lung injury and acute respiratory distress syndrome (ARDS) as well as diabetes, Cardiovascular event and associated comorbidities, which are the main causes of severe clinical problem in COVID-19 patients. Considering the protective role of vitamin D through modulating the innate and adaptive immune system as well as inhibition of Renin Angiotensin System (RAS), vitamin D supplementation might boost the immune system of COVID-19 patients and reduce severity of the disease in vitamin D deficient individuals.


vitamin D; ACE2; diabetes; cardiovascular disease


MEDICINE & PHARMACOLOGY, General Medical Research

Comments (1)

Comment 1
Received: 20 June 2020
The commenter has declared there is no conflict of interests.
Comment: Comprehensive, and strong on biochemical mechanisms.

Since you cover so much, it could be good to discuss importance of testing 25(OH)D, or (if that is too expensive) CRP as a proxy

or discuss daily sun exposure, and dosages:

simply supplementing at say 4000iu/day after an initial dose of say 50,000iu in those likely to be significantly D3 deficient.

Lower doses are unlikely to be effective and it's important to say this with courage, citing the evidence.

Consider co-factors also, and NAD+ or SiRT-1 pathways

More refs here:
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