Preserved in Portico This version is not peer-reviewed
Role of Vitamin D in Pathogenesis and Severity of COVID-19 Infection
: Received: 19 April 2020 / Approved: 20 April 2020 / Online: 20 April 2020 (01:37:43 CEST)
A peer-reviewed article of this Preprint also exists.
Journal reference: The Journal of Metabolic Diseases 2020
Coronavirus disease (COVID-19) is an infectious disease caused by a new virus which causes respiratory illness. Older adults and people who have previous chronic medical conditions are at higher risk for more serious complications from COVID-19.Hypovitaminosis D is attributed to the increased risk of lung injury and acute respiratory distress syndrome (ARDS) as well as diabetes, Cardiovascular event and associated comorbidities, which are the main causes of severe clinical problem in COVID-19 patients. Considering the protective role of vitamin D through modulating the innate and adaptive immune system as well as inhibition of Renin Angiotensin System (RAS), vitamin D supplementation might boost the immune system of COVID-19 patients and reduce severity of the disease in vitamin D deficient individuals.
vitamin D; ACE2; diabetes; cardiovascular disease
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