Version 1
: Received: 18 April 2020 / Approved: 19 April 2020 / Online: 19 April 2020 (01:35:58 CEST)
Version 2
: Received: 2 May 2020 / Approved: 4 May 2020 / Online: 4 May 2020 (19:12:33 CEST)
Version 3
: Received: 16 May 2020 / Approved: 17 May 2020 / Online: 17 May 2020 (14:51:39 CEST)
How to cite:
Kini, R.M.; Kundu, S. Infection-Genomics of COVID-19: Are Some Communities Resistant?. Preprints2020, 2020040310. https://doi.org/10.20944/preprints202004.0310.v2
Kini, R.M.; Kundu, S. Infection-Genomics of COVID-19: Are Some Communities Resistant?. Preprints 2020, 2020040310. https://doi.org/10.20944/preprints202004.0310.v2
Kini, R.M.; Kundu, S. Infection-Genomics of COVID-19: Are Some Communities Resistant?. Preprints2020, 2020040310. https://doi.org/10.20944/preprints202004.0310.v2
APA Style
Kini, R.M., & Kundu, S. (2020). Infection-Genomics of COVID-19: Are Some Communities Resistant?. Preprints. https://doi.org/10.20944/preprints202004.0310.v2
Chicago/Turabian Style
Kini, R.M. and Swati Kundu. 2020 "Infection-Genomics of COVID-19: Are Some Communities Resistant?" Preprints. https://doi.org/10.20944/preprints202004.0310.v2
Abstract
The 2019-Novel Coronavirus has currently gripped the world in terror, affecting 210 countries and territories as of April 29, 2020. Originating from Wuhan, Hubei province, China, the virus has spread so rapidly throughout the world and has already claimed 218,000 lives and is currently afflicting 3.14 million people.The US has over 1.03 million confirmed cases of COVID-19, followed by Spain, Italy, France, UK, Germany, Turkey, Russia, Iran, and China. On careful inspection of the COVID-19 statistics, a peculiar unsettling trend becomes apparent. Western European countries and the US appear to have difficulties in overcoming the catastrophe. In contrast, countries in East Asia, Middle East and mid-Europe have sorted out the situation. Here, we will highlight this trend and propose the importance of infection-genomics (sankramikogenomics), in understanding the susceptibility to COVID-19 and the severity of disease progress. More detailed evaluation may also identify more susceptible populations. Such differences are due to variations in structure or tissue-specific expression (alternate splicing and accessibility) of the target receptors. So, we will highlight mere 12-fold lower affinity is insufficient to ignore CD147, as interactions occur between tens of spike proteins and equal number of cell surface ACE2 and/or CD147. Similar to pharmacogenomics to drug development and precision medicine, Sankramikogenomics will become an important field in other infectious diseases and pathogenicity.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Commenter: R. Manjunatha Kini
Commenter's Conflict of Interests: Author