Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Signaling Pathways in Cervical Cancer Chemoresistance: Are microRNAs and Long-Noncoding RNAs the Main Culprits?

Version 1 : Received: 16 April 2020 / Approved: 17 April 2020 / Online: 17 April 2020 (08:12:52 CEST)

How to cite: Mousavi, S.R.; Hemmat, N.; Bannazadeh Baghi, H.; Derakhshani, A.; Tommasi, S.; Brunetti, O.; Baradaran, B.; Silvestris, N. Signaling Pathways in Cervical Cancer Chemoresistance: Are microRNAs and Long-Noncoding RNAs the Main Culprits?. Preprints 2020, 2020040294 (doi: 10.20944/preprints202004.0294.v1). Mousavi, S.R.; Hemmat, N.; Bannazadeh Baghi, H.; Derakhshani, A.; Tommasi, S.; Brunetti, O.; Baradaran, B.; Silvestris, N. Signaling Pathways in Cervical Cancer Chemoresistance: Are microRNAs and Long-Noncoding RNAs the Main Culprits?. Preprints 2020, 2020040294 (doi: 10.20944/preprints202004.0294.v1).

Abstract

Cervical cancer is known as one of the most important cancers in women worldwide. Chemotherapy is a standard treatment for advanced/recurrent cervical cancer in which the prognosis of the disease is really poor and the 1-year survival chance in these patients is maximally 20%. However, resistance to anticancer drugs is a major problem in treating cancer. Cervical cancer stem cells are considered as a fundamental cause of chemo and radio-resistance and also relapse after primary successful treatment. Signaling pathways include a wide range of molecular mechanisms contribute to drug resistance. Recently, microRNAs (miRNAs) are announced as a group of molecular biomarkers involving in response to chemotherapy in cancer patients. As the miRNAs, there are some long non-coding RNAs (LncRNAs) which their aberrant expression is considered as a biomarker for monitoring chemoresistance. In this review, we summarized current reports about the involvement of signaling pathways during chemoresistance in cervical cancer. Then, genes that have been demonstrated their involvement during drug resistance in cervical cancer were tabulated. Further, miRNAs that have been reported as biomarkers during treatment are listed. By bioinformatic analysis, we predictedmiR-335-5p and miR-16-5p as the most potential biomarkers for monitoring resistance to chemotherapy. Finally, long non-coding RNAs that have been introduced in recent studies as novel biomarkers during the response to chemotherapy were mentioned.

Subject Areas

signaling pathway; microRNA; long-noncoding RNA; chemoresistence; cervical cancer

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