Preserved in Portico This version is not peer-reviewed
Systems Biology Approach to Characterize Potential SARS-CoV-2 Pathways Based on Protein Functional Motifs
: Received: 9 April 2020 / Approved: 10 April 2020 / Online: 10 April 2020 (13:22:27 CEST)
: Received: 15 May 2020 / Approved: 16 May 2020 / Online: 16 May 2020 (18:54:17 CEST)
A peer-reviewed article of this Preprint also exists.
Journal reference: COVID 2021, 1, 384
Although phylogenetic analysis shows coronaviruses (CoV) share similar genome sequences, CoVs encode different number of proteins (5 to 14), which has implication on viral pathogenicity and infection. Here, we aimed to identify (in-silico) the similarities between different members of coronavirus family. The analysis included 50 coronavirus proteomes, including SARS-CoV-2 (COVID-19), to find the variation of the number of protein functional motifs and domain in each coronavirus. For this role, we used the experimentally validated domain (motif) that known to be crucial for viral infection. Although human CoVs are classified within one genus, we found variations among them. SARS-CoV-1, SARS-CoV-2 and MERS-CoV encode different type of domains, which has implications on the molecular interactions triggered by each virus within human cells. Secondly, we used functional motifs to reconstruct the potential molecular pathways or interactions triggered by SARS-CoV-2 proteins within human cell.
protein functional domains; short linear motifs; coronaviruses; COVID-19; severe acute respiratory syndrome-related coronavirus; 2019-nCoV; virus outbreak
LIFE SCIENCES, Virology
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