Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

The Human-Covid Tango: Connecting the Dots

Version 1 : Received: 8 April 2020 / Approved: 9 April 2020 / Online: 9 April 2020 (14:48:21 CEST)
Version 2 : Received: 13 April 2020 / Approved: 14 April 2020 / Online: 14 April 2020 (14:34:43 CEST)

How to cite: Hamdi, H.; Abdaldayem, E. The Human-Covid Tango: Connecting the Dots. Preprints 2020, 2020040160. Hamdi, H.; Abdaldayem, E. The Human-Covid Tango: Connecting the Dots. Preprints 2020, 2020040160.


As the world grapples with a hot pandemic with various and expanding epicenters, a flurry of medical and scientific activity has gained speed and momentum in a race to halt Covid-19. Due to the urgency of the situation, publication peer review has been speeded up to get information published and turn the gears of research in search for a cure. A hot and controversial topic has been the connection between Covid-19 and the Renin-angiotensin system (RAS). Covid-19, like Sars before it, enters by way of the Angiotensin Converting Enzyme 2 (ACE2). ACE2 is ubiquitously expressed in many tissues in the body serving as the doorway by which the virus can enter and spread causing inflammatory havoc. Demographic evidence coming out of china and other locations make it clear that the elderly and those suffering cardiovascular complications such as hypertension etc are most at risk. The connection to RAS and the demographic nature of the data coming out has led many to advance hypothesis, recommendations and even therapies based on existing RAS inhibitors and other components of the renin-angiotensin system. It is pertinent to review the literature in the context of our understanding of the renin-angiotesnin system to allow better judgements to be made as well as lines of research initiated advancing a quick resolution to Covid-19.


Covid-19; ACE2; AT1; AT2; Angiotensin; ACE; ACE inhibitors; Angiotensin Receptor Blockers


Medicine and Pharmacology, Epidemiology and Infectious Diseases

Comments (1)

Comment 1
Received: 12 April 2020
Commenter: Hawazen Hirbawi
The commenter has declared there is no conflict of interests.
Comment: This is the first time that I have heard of an explanation of why children have a benign Coronavirus infection, while adults have a virulent infection. This is a logical argument and has to be considered in the medical community. The contrast made between the renin-angiotenisn system in adults and children in the context of Coronavirus is brilliant. Hawazen Hirbawi, MD
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