Preprint Communication Version 1 Preserved in Portico This version is not peer-reviewed

COVID-19 Pandemic: Can Maintaining Optimal Zinc Balance Enhance Host Resistance?

Version 1 : Received: 29 March 2020 / Approved: 1 April 2020 / Online: 1 April 2020 (09:30:36 CEST)

A peer-reviewed article of this Preprint also exists.


The novel coronavirus, COVID-19 is now officially declared as a pandemic by the World Health Organization (WHO), and most parts of the world are taking drastic measures to restrict human movements to contain the infection. Like millions of others around the world, I am wondering, is there anything that could be done, other than keeping high personal hygiene, and be vigilant of symptoms, to reduce the chances of infection, or at least to reduce the burden of the disease. So far, the National and International health agencies, including the National Institutes of Health (NIH), the Centers for Disease Control and Prevention (CDC), and the WHO have provided clear guidelines for both preventive and treatment suggestions. In this opinion-based article, I want to discuss, why keeping the adequate micronutrient balance might enhance the host response and be protective of viral infections. A detailed in-depth discussion of various micronutrients is not the purpose of this article, I will mostly emphasize on the role of zinc in viral infection.


zinc; antiviral; COVID-19; pandemic; host resistance


Biology and Life Sciences, Virology

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