: Received: 26 March 2020 / Approved: 30 March 2020 / Online: 30 March 2020 (05:03:23 CEST)
: Received: 16 April 2020 / Approved: 17 April 2020 / Online: 17 April 2020 (12:49:49 CEST)
Komoshvili, K.; Becker, T.; Levitan, J.; Yahalom, A.; Barbora, A.; Liberman-Aronov, S. Morphological Changes in H1299 Human Lung Cancer Cells Following W-Band Millimeter-Wave Irradiation. Appl. Sci.2020, 10, 3187.
Komoshvili, K.; Becker, T.; Levitan, J.; Yahalom, A.; Barbora, A.; Liberman-Aronov, S. Morphological Changes in H1299 Human Lung Cancer Cells Following W-Band Millimeter-Wave Irradiation. Appl. Sci. 2020, 10, 3187.
Efficiently targeted cancer therapy without causing detrimental side effects is necessary for alleviating patient care and improving survival rates. This paper presents observations of morphological changes in H1299 human lung cancer cells following W-band MMW irradiation (75 – 105 GHz) at a non-thermal power density of 0.2 mW/cm2, investigated over 14 days of subsequent physiological incubation following exposure. Microscopic analyses of physical parameters measured indicate MMW irradiation induces significant morphological changes characteristic of apoptosis and senescence. The Immediate short-term responses translate into long-term effects, retained over the duration of the experiment(s); reminiscent of the phenomenon of Accelerated Cellular Senescence (ACS) achieving terminal tumorigenic cell growth. Further, results were observed to be treatment-specific in energy (dose) dependent manner and were achieved without the use of chemotherapeutic agents, ionizing radiation or thermal ablation employed in conventional methods; thereby overcoming associated side effects. Adaptation of the experimental parameters of this study for clinical oncology concomitant with current developmental trends of non-invasive medical endoscopy alleviates MMW therapy as an effective treatment procedure for human non-small cell lung cancer (NSCLC).
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.